Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A0DQ-01A-11R-A084-07

· A

3d45754f-0075-5af9-b59a-b67060f9b5be

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
3

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ANGIOGENESIS+0.560
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.560
  • TGF_BETA_SIGNALING+0.480
  • COAGULATION+0.410
  • MYOGENESIS+0.410
  • ESTROGEN_RESPONSE_EARLY+0.360
  • ESTROGEN_RESPONSE_LATE+0.360
  • PANCREAS_BETA_CELLS+0.310
  • COMPLEMENT+0.300
  • APICAL_JUNCTION+0.290

Top 10 suppressed

  • MYC_TARGETS_V2-0.570
  • MYC_TARGETS_V1-0.340
  • UNFOLDED_PROTEIN_RESPONSE-0.280
  • E2F_TARGETS-0.270
  • MTORC1_SIGNALING-0.250
  • ALLOGRAFT_REJECTION-0.240
  • OXIDATIVE_PHOSPHORYLATION-0.220
  • G2M_CHECKPOINT-0.180
  • CHOLESTEROL_HOMEOSTASIS-0.130
  • GLYCOLYSIS-0.120

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2208943
melanoma-umap@29
0.820
2SRR8518128
breast-umap@18
A0.813
3TCGA-BH-A0AZ-01A-21R-A12P-07
breast-umap@18
A0.781
4SRR8942951
bladder-landscape@3
0.774
5MNG306
mng-umap@100
0.766
6TCGA-FD-A5BZ-01A-11R-A28M-07
bladder-landscape@3
0.764
7SRR27320696
colon-landscapes@1
0.761
8TCGA-CN-6016-01A-11R-1686-07
head-neck@1
0.760
9SRR8518203
breast-umap@18
A0.759
10SRR5088898
melanoma-umap@29
0.759

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.560Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.560Inavolisib— uncovered
TGF_BETA_SIGNALING0.480Inavolisib— uncovered
COAGULATION0.410Binimetinib— uncovered
MYOGENESIS0.410Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.360Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.360Idelalisib— uncovered
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
COMPLEMENT0.300Inavolisib— uncovered
APICAL_JUNCTION0.290Inavolisib— uncovered
HEDGEHOG_SIGNALING0.280Inavolisib— uncovered
UV_RESPONSE_DN0.280Inavolisib— uncovered
APOPTOSIS0.270Idelalisib— uncovered
BILE_ACID_METABOLISM0.270Inavolisib— uncovered
P53_PATHWAY0.270Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.250Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.200Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.190Inavolisib— uncovered
KRAS_SIGNALING_UP0.190Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.160Inavolisib— uncovered