Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR29022837

· F

3e9e8502-ba6a-5406-8160-d492fde314ca

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
F
subtype
F

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8518149
breast-umap@18
F0.806
2SRR8518401
breast-umap@18
F0.785
3SRR8518325
breast-umap@18
F0.754
4TCGA-CN-4726-01A-01R-1436-07
head-neck@1
0.740
5SRR8518177
breast-umap@18
F0.730
6SRR8518286
breast-umap@18
F0.719
7C3N-03238
lung-landscapes@6
cohortA40.710
8SRR4195681
colon-landscapes@1
0.708
9SRR35579831
breast-umap@18
C0.706
10SRR8518315
breast-umap@18
F0.697

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANDROGEN_RESPONSE0.440Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.360Inavolisib— uncovered
MTORC1_SIGNALING0.340Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.330Remibrutinib— uncovered
XENOBIOTIC_METABOLISM0.290Inavolisib— uncovered
P53_PATHWAY0.280Idelalisib— uncovered
ALLOGRAFT_REJECTION0.270Idelalisib— uncovered
GLYCOLYSIS0.270Inavolisib— uncovered
PROTEIN_SECRETION0.270Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.250Inavolisib— uncovered
PEROXISOME0.250Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.250Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.230Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.220Idelalisib— uncovered
PANCREAS_BETA_CELLS0.200Cobimetinib— uncovered
IL2_STAT5_SIGNALING0.180Idelalisib— uncovered
COAGULATION0.170Binimetinib— uncovered
BILE_ACID_METABOLISM0.150Inavolisib— uncovered
KRAS_SIGNALING_UP0.140Inavolisib— uncovered
COMPLEMENT0.130Inavolisib— uncovered