Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · colon-landscapes@1

SRR27320672

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3f952a1c-fef6-5ee2-98f5-98aeb1b6d152

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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age_years
81

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.400
  • PROTEIN_SECRETION+0.400
  • PI3K_AKT_MTOR_SIGNALING+0.310
  • MTORC1_SIGNALING+0.290
  • OXIDATIVE_PHOSPHORYLATION+0.260
  • ANDROGEN_RESPONSE+0.200
  • CHOLESTEROL_HOMEOSTASIS+0.190
  • SPERMATOGENESIS+0.170
  • COMPLEMENT+0.160
  • DNA_REPAIR+0.160

Top 10 suppressed

  • NOTCH_SIGNALING-0.440
  • HEDGEHOG_SIGNALING-0.370
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
  • ANGIOGENESIS-0.300
  • APICAL_SURFACE-0.290
  • WNT_BETA_CATENIN_SIGNALING-0.270
  • TGF_BETA_SIGNALING-0.190
  • HYPOXIA-0.160
  • MYOGENESIS-0.140
  • MITOTIC_SPINDLE-0.120

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AUR-AERW-TTM1-A-1-1-R-A742-41
breast-umap@18
—C0.752
2SRR1797278
lung-landscapes@6
—cohortSC0.746
3a3b44031-71ef-476f-a8bd-3694226ce026
colon-landscapes@1
——0.744
4SRR29022835
breast-umap@18
—C0.732
5SRR33532785
breast-umap@18
—C0.717
6TCGA-38-4631-01A-01R-1755-07
lung-landscapes@6
—cohortA40.714
7dfb9c45f-cb52-4e36-b663-1a9e8c7c0b47
colon-landscapes@1
——0.713
8MNG637
mng-umap@100
——0.711
9TCGA-22-4594-01A-01R-1201-07
lung-landscapes@6
—cohortA30.711
10TCGA-AO-A0JD-01A-11R-A056-07
breast-umap@18
—C0.702

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.400Cobimetinib— uncovered
PROTEIN_SECRETION0.400Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.310Inavolisib— uncovered
MTORC1_SIGNALING0.290Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.260Remibrutinib— uncovered
ANDROGEN_RESPONSE0.200Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.190Remibrutinib— uncovered
SPERMATOGENESIS0.170Inavolisib— uncovered
COMPLEMENT0.160Inavolisib— uncovered
DNA_REPAIR0.160Idelalisib— uncovered
HEME_METABOLISM0.150Temsirolimus— uncovered
INTERFERON_GAMMA_RESPONSE0.140Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.130Inavolisib— uncovered
E2F_TARGETS0.120Inavolisib— uncovered
KRAS_SIGNALING_UP0.120Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.120Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.120Inavolisib— uncovered
ADIPOGENESIS0.110Inavolisib— uncovered
MYC_TARGETS_V10.110Inavolisib— uncovered
UV_RESPONSE_UP0.100Idelalisib— uncovered