BS_8NY9J9NQ
Meningioma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Meningioma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- Meningioma
- age_years
- 15.581
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.445
- OXIDATIVE_PHOSPHORYLATION+0.408
- UNFOLDED_PROTEIN_RESPONSE+0.335
- DNA_REPAIR+0.333
- MYC_TARGETS_V1+0.311
- INTERFERON_GAMMA_RESPONSE+0.304
- PROTEIN_SECRETION+0.285
- PI3K_AKT_MTOR_SIGNALING+0.279
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.248
- UV_RESPONSE_DN+0.233
Top 10 suppressed
- PANCREAS_BETA_CELLS-0.296
- HEDGEHOG_SIGNALING-0.243
- TNFA_SIGNALING_VIA_NFKB-0.235
- HYPOXIA-0.166
- KRAS_SIGNALING_UP-0.166
- KRAS_SIGNALING_DN-0.155
- MITOTIC_SPINDLE-0.137
- SPERMATOGENESIS-0.094
- WNT_BETA_CATENIN_SIGNALING-0.088
- CHOLESTEROL_HOMEOSTASIS-0.042
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_X2QTK3QD | Meningioma | — | 0.861 |
| 2 | BS_MM20BVW9 | Meningioma | — | 0.842 |
| 3 | BS_A3QZB9Y2 | Meningioma | — | 0.827 |
| 4 | BS_JAEM78XS | Meningioma | — | 0.825 |
| 5 | BS_QW60M0FE | Meningioma | — | 0.800 |
| 6 | BS_JGPR9SR2 | Meningioma | — | 0.772 |
| 7 | BS_W72364MN | Meningioma | — | 0.756 |
| 8 | 0636DD62-C493-47CC-A120-9759FB6980CD | — | — | 0.739 |
| 9 | MNG1200 | — | — | 0.730 |
| 10 | F42071CA-8794-4C79-8B02-8D48C70E8BA1 | — | — | 0.721 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 36 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.445 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.408 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.335 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.333 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.311 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.304 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.285 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.279 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.248 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.233 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.207 | Temsirolimus | — uncovered |
| NOTCH_SIGNALING | 0.207 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.197 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.191 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.178 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.173 | Inavolisib | — uncovered |
| PEROXISOME | 0.155 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.154 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.153 | Inavolisib | — uncovered |
| APOPTOSIS | 0.138 | Idelalisib | — uncovered |