Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

R187

4152a772-ccf0-5551-8995-a2427fe82b6c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8518216
breast-umap@18
D0.864
2bfb2d782-49b2-4452-b418-bc90cd007df1
colon-landscapes@1
0.862
3TCGA-D6-6515-01A-21R-1873-07
head-neck@1
0.858
4ea0e56e4-d9e3-44a2-9bdb-2e98554f6bff
colon-landscapes@1
0.854
5SRR6013597
lung-landscapes@6
cohortA10.854
6MNG523
mng-umap@100
0.852
7TCGA-CN-4733-01A-02R-1873-07
head-neck@1
0.852
8TCGA-DK-A3IU-01A-11R-A20F-07
bladder-landscape@3
0.849
9TCGA-CN-5370-01A-01R-2016-07
head-neck@1
0.846
10TCGA-BH-A1F0-01A-11R-A137-07
breast-umap@18
D0.844

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.650Inavolisib— uncovered
ALLOGRAFT_REJECTION0.620Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.600Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.520Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.470Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.470Idelalisib— uncovered
COMPLEMENT0.430Inavolisib— uncovered
IL2_STAT5_SIGNALING0.380Idelalisib— uncovered
ANGIOGENESIS0.360Remibrutinib— uncovered
COAGULATION0.300Binimetinib— uncovered
HEDGEHOG_SIGNALING0.250Inavolisib— uncovered
KRAS_SIGNALING_UP0.250Inavolisib— uncovered
PROTEIN_SECRETION0.240Remibrutinib— uncovered
APOPTOSIS0.200Idelalisib— uncovered
NOTCH_SIGNALING0.200Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.190Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.180Inavolisib— uncovered
APICAL_JUNCTION0.170Inavolisib— uncovered
UV_RESPONSE_DN0.170Inavolisib— uncovered
MYOGENESIS0.110Inavolisib— uncovered