Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

ERR2278870

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4190c4a3-2296-59f7-81dc-44b65d94de01

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.410
  • OXIDATIVE_PHOSPHORYLATION+0.400
  • MYC_TARGETS_V2+0.330
  • CHOLESTEROL_HOMEOSTASIS+0.230
  • DNA_REPAIR+0.230
  • UV_RESPONSE_UP+0.220
  • PEROXISOME+0.210
  • E2F_TARGETS+0.200
  • ADIPOGENESIS+0.190
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.190

Top 10 suppressed

  • MITOTIC_SPINDLE-0.450
  • HEDGEHOG_SIGNALING-0.330
  • PROTEIN_SECRETION-0.280
  • MYOGENESIS-0.260
  • INTERFERON_GAMMA_RESPONSE-0.250
  • PI3K_AKT_MTOR_SIGNALING-0.250
  • INTERFERON_ALPHA_RESPONSE-0.240
  • UV_RESPONSE_DN-0.230
  • TGF_BETA_SIGNALING-0.210
  • G2M_CHECKPOINT-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1f844415e-ca2a-4837-b050-06775fdb2ed5
colon-landscapes@1
——0.797
2TCGA-AC-A62V-01A-11R-A31O-07
breast-umap@18
—B0.773
3d22c9285-50cf-4724-9f81-606fb54c00fc
colon-landscapes@1
——0.773
4TCGA-22-4607-01A-01R-1201-07
lung-landscapes@6
—cohortSQ10.771
5TCGA-E2-A574-01A-11R-A29R-07
breast-umap@18
—E0.752
6TCGA-E9-A1RG-01A-11R-A14D-07
breast-umap@18
—B0.749
7TCGA-A2-A3XV-01A-21R-A239-07
breast-umap@18
—B0.748
80acddbbc-6b74-4fdd-903d-f5ec9bfd8514
colon-landscapes@1
——0.743
9TCGA-P3-A5Q6-01A-11R-A28V-07
head-neck@1
——0.735
10d837c3e6-ef78-42a0-8a39-c57d48bc7c3a
colon-landscapes@1
——0.731

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.410de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
OXIDATIVE_PHOSPHORYLATION0.400f899e40c-36d9-5159-bb34-76e0b142a283— uncovered
MYC_TARGETS_V20.330f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
CHOLESTEROL_HOMEOSTASIS0.230f899e40c-36d9-5159-bb34-76e0b142a283— uncovered
DNA_REPAIR0.230f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
UV_RESPONSE_UP0.220f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
PEROXISOME0.210f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
E2F_TARGETS0.200de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
ADIPOGENESIS0.190de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.190de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
MTORC1_SIGNALING0.160de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
PANCREAS_BETA_CELLS0.1400873dc16-6964-5b66-9fa5-8388ccd977e8— uncovered
XENOBIOTIC_METABOLISM0.130de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.110de76dd36-fa97-5a88-a5af-c6c372f4a32b— uncovered
UNFOLDED_PROTEIN_RESPONSE0.110f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
COAGULATION0.100f9416d2c-9018-5d3a-89af-90d2127a0fba— uncovered
KRAS_SIGNALING_DN0.100f899e40c-36d9-5159-bb34-76e0b142a283— uncovered
ALLOGRAFT_REJECTION0.090f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
ESTROGEN_RESPONSE_LATE0.090f3f10ff3-a677-5498-82b6-114b75e284b3— uncovered
APICAL_SURFACE0.0800f25d289-3505-5810-9f68-ee711fc00ed1— uncovered