MDT-AP-0113
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- age_years
- 11
- sex
- M
- new_clusters
- C6
- umap1_2d
- 3.029978784
- umap2_2d
- 6.411356911
- umap1_3d
- 2.046663207
- umap2_3d
- -1.014944199
- umap3_3d
- -5.043618746
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-3021 | Med | Medulloblastoma | 0.948 |
| 2 | MDT-AP-2917 | Med | Medulloblastoma | 0.938 |
| 3 | BS_4CP4T22V | Med | Medulloblastoma | 0.936 |
| 4 | MDT-AP-0382 | Med | Medulloblastoma | 0.936 |
| 5 | BS_DFWFBYSN | medulloblastoma | — | 0.922 |
| 6 | BS_J8G4SH4Z | Med | Medulloblastoma | 0.922 |
| 7 | SRR661290 | GTEX | — | 0.921 |
| 8 | SRR662871 | GTEX | — | 0.921 |
| 9 | BS_4CP4T22V | medulloblastoma | — | 0.920 |
| 10 | SRR1080927 | GTEX | — | 0.918 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.360 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.350 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.320 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.300 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.290 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.200 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.190 | Temsirolimus | — uncovered |
| ADIPOGENESIS | 0.090 | Inavolisib | — uncovered |
| PEROXISOME | 0.090 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.070 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.070 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.040 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.040 | Idelalisib | — uncovered |