Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-E9-A1NE-01A-21R-A14M-07

· A

4588f376-2cad-5af0-b74e-403b6d02a4a4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
36
os_event
false

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR5088852
melanoma-umap@29
0.858
2SRR8518228
breast-umap@18
D0.854
3TCGA-55-8089-01A-11R-2241-07
lung-landscapes@6
cohortA10.850
4SRR8518454
breast-umap@18
D0.843
5C3N-03765
lung-landscapes@6
cohortA10.833
6SRR10900571
melanoma-umap@29
0.831
7MNG464
mng-umap@100
0.827
8BS_3MYEMXPQ
medullo-epn-umap@date-based
MedMedulloblastoma0.824
9MNG215
mng-umap@100
0.822
10TCGA-69-7974-01A-11R-2187-07
lung-landscapes@6
cohortA10.820

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 25 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_GAMMA_RESPONSE0.580Idelalisib— uncovered
ALLOGRAFT_REJECTION0.570Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.570Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.540Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.450Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.430Idelalisib— uncovered
COMPLEMENT0.380Inavolisib— uncovered
KRAS_SIGNALING_UP0.380Inavolisib— uncovered
IL2_STAT5_SIGNALING0.350Idelalisib— uncovered
PROTEIN_SECRETION0.350Remibrutinib— uncovered
TGF_BETA_SIGNALING0.350Inavolisib— uncovered
MITOTIC_SPINDLE0.300Inavolisib— uncovered
APOPTOSIS0.290Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.250Inavolisib— uncovered
G2M_CHECKPOINT0.190Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.180Inavolisib— uncovered
UV_RESPONSE_DN0.170Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.140Inavolisib— uncovered
ANDROGEN_RESPONSE0.130Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.110Idelalisib— uncovered