Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR26320076

45a558e3-5245-5e7f-ac4f-e9fca971b514

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1s_150324_4b
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.937
2EPT0508
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.928
3BS_N1E0H8YQ
brain-umap@2
low-grade glioma0.927
4MNG281
mng-umap@100
0.926
5EPT0509
medullo-epn-umap@date-based
EPNEPN Tumor0.921
6BS_EN2VK7NY
brain-umap@2
low-grade glioma0.919
7BS_WRHDP7WF
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.919
8BS_8RHPJ740
medullo-epn-umap@date-based
EPNEPN Tumor0.916
9TCGA-CN-6020-01A-11R-1686-07
head-neck@1
0.915
10SRR8518423
breast-umap@18
C0.915

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 45 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.700Inavolisib— uncovered
ANGIOGENESIS0.620Remibrutinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.600Inavolisib— uncovered
COAGULATION0.540Binimetinib— uncovered
MYOGENESIS0.530Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.510Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.480Idelalisib— uncovered
HYPOXIA0.470Idelalisib— uncovered
IL2_STAT5_SIGNALING0.440Idelalisib— uncovered
APICAL_JUNCTION0.420Inavolisib— uncovered
APOPTOSIS0.410Idelalisib— uncovered
COMPLEMENT0.410Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.410Idelalisib— uncovered
KRAS_SIGNALING_UP0.410Inavolisib— uncovered
UV_RESPONSE_DN0.390Inavolisib— uncovered
TGF_BETA_SIGNALING0.380Inavolisib— uncovered
ALLOGRAFT_REJECTION0.370Idelalisib— uncovered
ANDROGEN_RESPONSE0.360Inavolisib— uncovered
MTORC1_SIGNALING0.350Inavolisib— uncovered
UV_RESPONSE_UP0.350Idelalisib— uncovered