Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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TCGA-G2-A3IE-01A-11R-A20F-07

45e3edf4-acfd-5994-8e06-55c08fe6839c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
20.10512484
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • BILE_ACID_METABOLISM+0.160
  • KRAS_SIGNALING_DN+0.140
  • APICAL_SURFACE+0.070
  • PEROXISOME+0.050
  • PANCREAS_BETA_CELLS+0.040
  • NOTCH_SIGNALING+0.030
  • SPERMATOGENESIS-0.010
  • XENOBIOTIC_METABOLISM-0.010
  • ESTROGEN_RESPONSE_EARLY-0.020
  • ESTROGEN_RESPONSE_LATE-0.050

Top 10 suppressed

  • E2F_TARGETS-0.570
  • INTERFERON_ALPHA_RESPONSE-0.560
  • INTERFERON_GAMMA_RESPONSE-0.500
  • MYC_TARGETS_V1-0.500
  • G2M_CHECKPOINT-0.480
  • MTORC1_SIGNALING-0.480
  • UNFOLDED_PROTEIN_RESPONSE-0.460
  • TNFA_SIGNALING_VIA_NFKB-0.450
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.440
  • MITOTIC_SPINDLE-0.420

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-03420
lung-landscapes@6
cohortA10.943
2BS_0Y66ZBWE
brain-umap@2
low-grade glioma0.921
3C3N-02950
lung-landscapes@6
cohortA10.920
4SRR1313097
breast-umap@18
A0.919
5b03ebc32.a177.44c7.8b02.fcd6560712f2
lung-landscapes@6
cohortA10.910
6SRR1516063
bladder-landscape@3
0.910
7SRR1516050
bladder-landscape@3
0.905
8TCGA-XF-A8HG-01A-11R-A36F-07
bladder-landscape@3
0.905
9SRR1516067
bladder-landscape@3
0.899
10MNG540
mng-umap@100
0.898

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 6 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
BILE_ACID_METABOLISM0.160Inavolisib— uncovered
KRAS_SIGNALING_DN0.140Remibrutinib— uncovered
APICAL_SURFACE0.070Temsirolimus— uncovered
PEROXISOME0.050Idelalisib— uncovered
PANCREAS_BETA_CELLS0.040Cobimetinib— uncovered
NOTCH_SIGNALING0.030Inavolisib— uncovered