Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-UF-A7JO-01A-11R-A34R-07

464a460b-431b-5fac-ac6f-481af45632b2

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.144063927
sex
female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.660
  • INTERFERON_GAMMA_RESPONSE+0.580
  • OXIDATIVE_PHOSPHORYLATION+0.570
  • MYC_TARGETS_V1+0.500
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.500
  • ALLOGRAFT_REJECTION+0.480
  • MYC_TARGETS_V2+0.380
  • E2F_TARGETS+0.370
  • DNA_REPAIR+0.360
  • COMPLEMENT+0.350

Top 10 suppressed

  • UV_RESPONSE_DN-0.380
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.350
  • ANGIOGENESIS-0.300
  • ESTROGEN_RESPONSE_EARLY-0.300
  • MYOGENESIS-0.300
  • TGF_BETA_SIGNALING-0.290
  • WNT_BETA_CATENIN_SIGNALING-0.290
  • APICAL_JUNCTION-0.260
  • PANCREAS_BETA_CELLS-0.250
  • NOTCH_SIGNALING-0.220

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1992ce1bc-46a2-4f57-ac7a-c6368c69c67c
colon-landscapes@1
0.905
2TCGA-T2-A6WX-01A-12R-A34R-07
head-neck@1
0.876
3ERR2208905
melanoma-umap@29
0.876
42ad90ba0-8038-4bad-afa3-d176f63b42f0
colon-landscapes@1
0.876
5e0464181-da72-4a14-9039-a396843c39f2
colon-landscapes@1
0.868
6SRR8518156
breast-umap@18
D0.868
7TCGA-39-5011-01A-01R-1443-07
lung-landscapes@6
cohortA10.867
8TCGA-AR-A0U0-01A-11R-A109-07
breast-umap@18
E0.866
9ERR2208906
melanoma-umap@29
0.863
10TCGA-38-4625-01A-01R-1206-07
lung-landscapes@6
cohortA10.858

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.660Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.580Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.570Remibrutinib— uncovered
MYC_TARGETS_V10.500Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.500Inavolisib— uncovered
ALLOGRAFT_REJECTION0.480Idelalisib— uncovered
MYC_TARGETS_V20.380Idelalisib— uncovered
E2F_TARGETS0.370Inavolisib— uncovered
DNA_REPAIR0.360Idelalisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
MTORC1_SIGNALING0.340Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.280Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.280Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.280Inavolisib— uncovered
FATTY_ACID_METABOLISM0.260Inavolisib— uncovered
ADIPOGENESIS0.250Inavolisib— uncovered
UV_RESPONSE_UP0.240Idelalisib— uncovered
G2M_CHECKPOINT0.210Inavolisib— uncovered
IL2_STAT5_SIGNALING0.180Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.180Inavolisib— uncovered