SRR1475257
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.406
- SPERMATOGENESIS+0.284
- PANCREAS_BETA_CELLS+0.196
- MYOGENESIS+0.188
- APICAL_SURFACE+0.156
- APICAL_JUNCTION+0.096
- ESTROGEN_RESPONSE_LATE+0.096
- COAGULATION+0.074
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.073
- ESTROGEN_RESPONSE_EARLY+0.047
Top 10 suppressed
- MYC_TARGETS_V1-0.582
- UNFOLDED_PROTEIN_RESPONSE-0.548
- MYC_TARGETS_V2-0.526
- MTORC1_SIGNALING-0.517
- CHOLESTEROL_HOMEOSTASIS-0.497
- DNA_REPAIR-0.496
- E2F_TARGETS-0.463
- G2M_CHECKPOINT-0.462
- PROTEIN_SECRETION-0.448
- INTERFERON_ALPHA_RESPONSE-0.432
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1355262 | GTEX | — | 0.962 |
| 2 | SRR1341008 | GTEX | — | 0.958 |
| 3 | SRR1417505 | GTEX | — | 0.958 |
| 4 | SRR1336357 | GTEX | — | 0.957 |
| 5 | SRR1362417 | GTEX | — | 0.956 |
| 6 | SRR1402454 | GTEX | — | 0.955 |
| 7 | SRR1470397 | GTEX | — | 0.952 |
| 8 | SRR1313951 | GTEX | — | 0.952 |
| 9 | SRR1337074 | GTEX | — | 0.948 |
| 10 | SRR1398157 | GTEX | — | 0.948 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.406 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.284 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.196 | Cobimetinib | — uncovered |
| MYOGENESIS | 0.188 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.156 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.096 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.096 | Idelalisib | — uncovered |
| COAGULATION | 0.074 | Binimetinib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.073 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.047 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.033 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.012 | Inavolisib | — uncovered |