SRR8942963

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4b5e5dfb-c056-57ef-9b57-ab2e5ce89f1e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-33-4587-01A-11R-2125-07 lung-landscapes@6	—	cohortMD1	0.922
2	TCGA-O2-A5IB-01A-11R-A27Q-07 lung-landscapes@6	—	cohortMD1	0.920
3	TCGA-66-2793-01A-01R-1201-07 lung-landscapes@6	—	cohortMD1	0.914
4	C3L-04013 lung-landscapes@6	—	cohortMD1	0.912
5	TCGA-E7-A5KE-01A-11R-A28M-07 bladder-landscape@3	—	—	0.911
6	SRR3147738 colon-landscapes@1	—	—	0.908
7	TCGA-91-6847-01A-11R-1949-07 lung-landscapes@6	—	cohortMD1	0.904
8	BS_M0QYNVK8 brain-umap@2	high-grade glioma	—	0.903
9	ERR2208947 melanoma-umap@29	—	—	0.902
10	TCGA-A1-A0SO-01A-22R-A084-07 breast-umap@18	—	E	0.901

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 12 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
E2F_TARGETS	0.540	Inavolisib	— uncovered
G2M_CHECKPOINT	0.470	Inavolisib	— uncovered
MITOTIC_SPINDLE	0.380	Inavolisib	— uncovered
MYC_TARGETS_V2	0.240	Idelalisib	— uncovered
DNA_REPAIR	0.190	Idelalisib	— uncovered
SPERMATOGENESIS	0.190	Inavolisib	— uncovered
MYC_TARGETS_V1	0.160	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.040	Inavolisib	— uncovered
ADIPOGENESIS	0.030	Inavolisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.030	Inavolisib	— uncovered
UNFOLDED_PROTEIN_RESPONSE	0.030	Idelalisib	— uncovered
PROTEIN_SECRETION	0.020	Remibrutinib	— uncovered