TCGA-44-6148-01A-11R-1755-07
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 60
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-50-5942-01A-21R-1755-07 | — | cohortA1 | 0.942 |
| 2 | SRR8613705 | — | A | 0.932 |
| 3 | C3L-00444 | — | cohortA1 | 0.924 |
| 4 | SRR8613714 | — | A | 0.908 |
| 5 | TCGA-NJ-A55A-01A-11R-A262-07 | — | cohortA1 | 0.903 |
| 6 | b03ebc32.a177.44c7.8b02.fcd6560712f2 | — | cohortA1 | 0.900 |
| 7 | TCGA-55-8512-01A-11R-2403-07 | — | cohortA1 | 0.896 |
| 8 | C3N-02950 | — | cohortA1 | 0.896 |
| 9 | SRR8613701 | — | A | 0.895 |
| 10 | TCGA-56-8624-01A-11R-2403-07 | — | cohortSQ1 | 0.894 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.380 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.340 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.310 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.300 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.210 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.130 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.120 | Temsirolimus | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.120 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.090 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.080 | Temsirolimus | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.040 | Inavolisib | — uncovered |
| MYOGENESIS | 0.040 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.040 | Inavolisib | — uncovered |
| COAGULATION | 0.020 | Binimetinib | — uncovered |
| TGF_BETA_SIGNALING | 0.010 | Inavolisib | — uncovered |