Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_RGSMX7QD

Ganglioglioma

4e398174-5a01-5eea-b241-9edc3caa490f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Ganglioglioma
cancer_type_detailed
subtype
cancer_type
Ganglioglioma
age_years
10.795
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.517
  • PROTEIN_SECRETION+0.465
  • ANDROGEN_RESPONSE+0.357
  • ADIPOGENESIS+0.348
  • PANCREAS_BETA_CELLS+0.338
  • MTORC1_SIGNALING+0.325
  • BILE_ACID_METABOLISM+0.264
  • UV_RESPONSE_DN+0.244
  • FATTY_ACID_METABOLISM+0.211
  • UNFOLDED_PROTEIN_RESPONSE+0.204

Top 10 suppressed

  • G2M_CHECKPOINT-0.453
  • E2F_TARGETS-0.384
  • WNT_BETA_CATENIN_SIGNALING-0.246
  • MITOTIC_SPINDLE-0.189
  • ANGIOGENESIS-0.159
  • APICAL_JUNCTION-0.142
  • MYC_TARGETS_V2-0.125
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.102
  • DNA_REPAIR-0.068
  • UV_RESPONSE_UP-0.045

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_HV8PFRBR
brain-umap@2
pilocytic astrocytoma0.778
2BS_GHNJ4CYC
brain-umap@2
low-grade glioma0.777
3BS_N210XMKR
brain-umap@2
low-grade glioma0.776
4BS_2EMW8ZG3
brain-umap@2
low-grade glioma0.757
5BS_SDZY6RZ3
brain-umap@2
pilocytic astrocytoma0.754
6SRR8518149
breast-umap@18
F0.748
7BS_Y0PCBNJV
brain-umap@2
pilocytic astrocytoma0.746
8SRR8518337
breast-umap@18
F0.738
9BS_3Q0GTSYH
brain-umap@2
pilocytic astrocytoma0.738
10BS_66HQ3E4Z
brain-umap@2
pilocytic astrocytoma0.730

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.517Remibrutinib— uncovered
PROTEIN_SECRETION0.465Remibrutinib— uncovered
ANDROGEN_RESPONSE0.357Inavolisib— uncovered
ADIPOGENESIS0.348Inavolisib— uncovered
PANCREAS_BETA_CELLS0.338Cobimetinib— uncovered
MTORC1_SIGNALING0.325Inavolisib— uncovered
BILE_ACID_METABOLISM0.264Inavolisib— uncovered
UV_RESPONSE_DN0.244Inavolisib— uncovered
FATTY_ACID_METABOLISM0.211Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.204Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.203Remibrutinib— uncovered
NOTCH_SIGNALING0.184Inavolisib— uncovered
PEROXISOME0.180Idelalisib— uncovered
HEDGEHOG_SIGNALING0.174Inavolisib— uncovered
APOPTOSIS0.154Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.148Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.144Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.133Inavolisib— uncovered
ALLOGRAFT_REJECTION0.130Idelalisib— uncovered
IL2_STAT5_SIGNALING0.123Idelalisib— uncovered