TCGA-BA-A4IH-01A-11R-A266-07
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.460
- PANCREAS_BETA_CELLS+0.450
- SPERMATOGENESIS+0.380
- G2M_CHECKPOINT+0.310
- KRAS_SIGNALING_DN+0.140
- UV_RESPONSE_UP+0.020
- KRAS_SIGNALING_UP+0.010
- UV_RESPONSE_DN-0.010
- MYC_TARGETS_V1-0.020
- HEDGEHOG_SIGNALING-0.030
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.370
- COAGULATION-0.360
- APICAL_JUNCTION-0.350
- MYOGENESIS-0.340
- MYC_TARGETS_V2-0.330
- P53_PATHWAY-0.330
- ANGIOGENESIS-0.320
- PI3K_AKT_MTOR_SIGNALING-0.320
- OXIDATIVE_PHOSPHORYLATION-0.300
- NOTCH_SIGNALING-0.290
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_HHPA8NJ2 | medulloblastoma | — | 0.895 |
| 2 | BS_7FWZ518S | medulloblastoma | — | 0.862 |
| 3 | MNG1226 | — | — | 0.860 |
| 4 | SRR33346963 | — | — | 0.860 |
| 5 | SRR23303770 | — | — | 0.859 |
| 6 | C3L-02616 | — | cohortMD1 | 0.851 |
| 7 | BS_W311713R | medulloblastoma | — | 0.849 |
| 8 | BS_NZ71XCG3 | medulloblastoma | — | 0.843 |
| 9 | TCGA-DQ-7591-01A-11R-2081-07 | — | — | 0.837 |
| 10 | TCGA-BB-4224-01A-01R-1436-07 | — | — | 0.832 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.460 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.450 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.380 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.310 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.140 | Remibrutinib | — uncovered |
| UV_RESPONSE_UP | 0.020 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.010 | Inavolisib | — uncovered |