Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG272

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518998f1-833a-59c6-a45c-41e9d0ee93e1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1MNG1146
mng-umap@100
——0.950
2SRR602839
brain-umap@2
GTEX—0.946
3SRR934982
brain-umap@2
——0.945
4SRR1418604
brain-umap@2
GTEX—0.945
5SRR1362464
brain-umap@2
GTEX—0.944
6SRR659472
brain-umap@2
GTEX—0.943
7SRR1797250
lung-landscapes@6
—cohortMD20.936
8SRR1335064
brain-umap@2
GTEX—0.933
9SRR1476614
brain-umap@2
GTEX—0.933
10SRR1414424
brain-umap@2
GTEX—0.931

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.442Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.430Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.425Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.415Inavolisib— uncovered
KRAS_SIGNALING_DN0.408Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.382Cobimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.339Inavolisib— uncovered
COAGULATION0.329Binimetinib— uncovered
KRAS_SIGNALING_UP0.314Inavolisib— uncovered
APICAL_SURFACE0.313Temsirolimus— uncovered
IL6_JAK_STAT3_SIGNALING0.309Inavolisib— uncovered
COMPLEMENT0.293Inavolisib— uncovered
HYPOXIA0.194Idelalisib— uncovered
MYOGENESIS0.185Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.163Idelalisib— uncovered
IL2_STAT5_SIGNALING0.161Idelalisib— uncovered
SPERMATOGENESIS0.160Inavolisib— uncovered
BILE_ACID_METABOLISM0.137Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.127Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.012Inavolisib— uncovered