Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_8Z3SCKB5

subependymal giant cell astrocytoma(SEGA)

5229f367-1f1e-5dd9-ab46-1d6ab7077ae5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
subependymal giant cell astrocytoma(SEGA)
cancer_type_detailed
subtype
cancer_type
subependymal giant cell astrocytoma(SEGA)
overall_survival_months
47.273324572930356
age_years
10.679

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.661
  • INTERFERON_ALPHA_RESPONSE+0.618
  • INTERFERON_GAMMA_RESPONSE+0.549
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.535
  • IL6_JAK_STAT3_SIGNALING+0.499
  • FATTY_ACID_METABOLISM+0.470
  • ADIPOGENESIS+0.458
  • ALLOGRAFT_REJECTION+0.445
  • COAGULATION+0.437
  • PROTEIN_SECRETION+0.414

Top 10 suppressed

  • E2F_TARGETS-0.438
  • G2M_CHECKPOINT-0.382
  • MYC_TARGETS_V2-0.303
  • WNT_BETA_CATENIN_SIGNALING-0.233
  • MITOTIC_SPINDLE-0.232
  • SPERMATOGENESIS-0.160
  • MYC_TARGETS_V1-0.136
  • NOTCH_SIGNALING-0.129
  • TGF_BETA_SIGNALING-0.110
  • UV_RESPONSE_DN-0.095

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_3TQSE8HF
brain-umap@2
subependymal giant cell astrocytoma(SEGA)0.954
2BS_R634WKN7
brain-umap@2
subependymal giant cell astrocytoma(SEGA)0.930
3BS_VARR255N
brain-umap@2
pilocytic astrocytoma0.905
4SRR1078879
brain-umap@2
GTEX0.895
5SRR15030885
colon-landscapes@1
0.891
6BS_BKQZ550R
brain-umap@2
pilocytic astrocytoma0.891
7BS_X16PENSA
brain-umap@2
pilocytic astrocytoma0.891
8BS_HV8PFRBR
brain-umap@2
pilocytic astrocytoma0.888
9BS_JG9JZTA9
brain-umap@2
low-grade glioma0.884
10BS_EYYMKWB7
brain-umap@2
subependymal giant cell astrocytoma(SEGA)0.883

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 37 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.661Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.618Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.549Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.535Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.499Inavolisib— uncovered
FATTY_ACID_METABOLISM0.470Inavolisib— uncovered
ADIPOGENESIS0.458Inavolisib— uncovered
ALLOGRAFT_REJECTION0.445Idelalisib— uncovered
COAGULATION0.437Binimetinib— uncovered
PROTEIN_SECRETION0.414Remibrutinib— uncovered
APOPTOSIS0.382Idelalisib— uncovered
HEME_METABOLISM0.359Temsirolimus— uncovered
CHOLESTEROL_HOMEOSTASIS0.347Remibrutinib— uncovered
COMPLEMENT0.342Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.341Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.326Inavolisib— uncovered
BILE_ACID_METABOLISM0.311Inavolisib— uncovered
MTORC1_SIGNALING0.281Inavolisib— uncovered
IL2_STAT5_SIGNALING0.274Idelalisib— uncovered
PEROXISOME0.273Idelalisib— uncovered