Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-GD-A76B-01A-11R-A32O-07

57455369-94d3-57c7-8890-4ad8bce98617

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
os_event
true
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.490
  • ALLOGRAFT_REJECTION+0.410
  • INTERFERON_GAMMA_RESPONSE+0.340
  • BILE_ACID_METABOLISM+0.320
  • KRAS_SIGNALING_DN+0.300
  • INTERFERON_ALPHA_RESPONSE+0.280
  • IL6_JAK_STAT3_SIGNALING+0.270
  • INFLAMMATORY_RESPONSE+0.250
  • TNFA_SIGNALING_VIA_NFKB+0.210
  • FATTY_ACID_METABOLISM+0.200

Top 10 suppressed

  • G2M_CHECKPOINT-0.490
  • E2F_TARGETS-0.480
  • MITOTIC_SPINDLE-0.480
  • TGF_BETA_SIGNALING-0.480
  • MYC_TARGETS_V1-0.440
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.410
  • PROTEIN_SECRETION-0.380
  • MYC_TARGETS_V2-0.370
  • UV_RESPONSE_DN-0.350
  • ANGIOGENESIS-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-91-A4BD-01A-11R-A24H-07
lung-landscapes@6
cohortA10.893
2TCGA-GV-A3QK-01B-11R-A23N-07
bladder-landscape@3
0.865
3MNG1161
mng-umap@100
0.854
4TCGA-50-6597-01A-11R-1858-07
lung-landscapes@6
cohortA10.844
5ERR2598268
medullo-epn-umap@date-based
fetalfetal0.841
6SRR2778078
melanoma-umap@29
0.839
7SRR13780258
lung-landscapes@6
cohortMD20.835
8SJEPD040_D.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.832
928f73ee0-f218-4884-81c6-e6b4ba2fdccd
colon-landscapes@1
0.827
10855f0a82-04de-485d-9613-5ccf08074069
melanoma-umap@29
0.826

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.490Cobimetinib— uncovered
ALLOGRAFT_REJECTION0.410Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.340Idelalisib— uncovered
BILE_ACID_METABOLISM0.320Inavolisib— uncovered
KRAS_SIGNALING_DN0.300Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.280Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.270Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.250Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.210Inavolisib— uncovered
FATTY_ACID_METABOLISM0.200Inavolisib— uncovered
COMPLEMENT0.190Inavolisib— uncovered
PEROXISOME0.170Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.170Inavolisib— uncovered
KRAS_SIGNALING_UP0.120Inavolisib— uncovered
MYOGENESIS0.120Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.110Idelalisib— uncovered
SPERMATOGENESIS0.100Inavolisib— uncovered
APICAL_SURFACE0.090Temsirolimus— uncovered
ESTROGEN_RESPONSE_EARLY0.070Inavolisib— uncovered
IL2_STAT5_SIGNALING0.070Idelalisib— uncovered