Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1338923

GTEX

58071703-6b4a-5c16-ab98-9b10b045d272

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1491293
brain-umap@2
GTEX0.955
2SRR1352954
brain-umap@2
GTEX0.944
3BS_3XY76V8T
brain-umap@2
Ganglioglioma0.937
4SRR1345478
brain-umap@2
GTEX0.929
5SRR1442666
brain-umap@2
GTEX0.929
6SRR1339968
brain-umap@2
GTEX0.928
7SRR1472150
brain-umap@2
GTEX0.927
8MDT-AP-2892
medullo-epn-umap@date-based
MedMedulloblastoma0.924
9SRR1335707
brain-umap@2
GTEX0.922
10SRR1479779
brain-umap@2
GTEX0.922

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.445Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.431Inavolisib— uncovered
COAGULATION0.403Binimetinib— uncovered
MYOGENESIS0.390Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.359Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.351Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.339Inavolisib— uncovered
ANGIOGENESIS0.327Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.325Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.309Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.297Idelalisib— uncovered
PANCREAS_BETA_CELLS0.297Cobimetinib— uncovered
XENOBIOTIC_METABOLISM0.275Inavolisib— uncovered
ALLOGRAFT_REJECTION0.247Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.247Inavolisib— uncovered
APOPTOSIS0.240Idelalisib— uncovered
IL2_STAT5_SIGNALING0.232Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.222Inavolisib— uncovered
BILE_ACID_METABOLISM0.205Inavolisib— uncovered
FATTY_ACID_METABOLISM0.194Inavolisib— uncovered