MNG1139
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.464
- KRAS_SIGNALING_DN+0.331
- SPERMATOGENESIS+0.310
- COAGULATION+0.240
- APICAL_SURFACE+0.222
- TNFA_SIGNALING_VIA_NFKB+0.211
- ESTROGEN_RESPONSE_LATE+0.206
- ESTROGEN_RESPONSE_EARLY+0.133
- HEDGEHOG_SIGNALING+0.099
- COMPLEMENT-0.004
Top 10 suppressed
- MYC_TARGETS_V2-0.534
- DNA_REPAIR-0.442
- MITOTIC_SPINDLE-0.430
- UNFOLDED_PROTEIN_RESPONSE-0.400
- ADIPOGENESIS-0.386
- MTORC1_SIGNALING-0.349
- MYC_TARGETS_V1-0.345
- PI3K_AKT_MTOR_SIGNALING-0.339
- OXIDATIVE_PHOSPHORYLATION-0.337
- TGF_BETA_SIGNALING-0.324
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1150 | — | — | 0.938 |
| 2 | MNG1149 | — | — | 0.915 |
| 3 | MNG225 | — | — | 0.908 |
| 4 | SRR1468974 | GTEX | — | 0.903 |
| 5 | MNG1118 | — | — | 0.893 |
| 6 | MNG466 | — | — | 0.892 |
| 7 | SRR1340301 | GTEX | — | 0.890 |
| 8 | MNG1123 | — | — | 0.889 |
| 9 | SRR1320342 | GTEX | — | 0.887 |
| 10 | BS_EXYHZ6D4 | pilocytic astrocytoma | — | 0.886 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.464 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.331 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.310 | Inavolisib | — uncovered |
| COAGULATION | 0.240 | Binimetinib | — uncovered |
| APICAL_SURFACE | 0.222 | Temsirolimus | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.211 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.206 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.133 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.099 | Inavolisib | — uncovered |