MBCProject_0719_T1_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.460
- NOTCH_SIGNALING+0.190
- HEDGEHOG_SIGNALING+0.110
- MYC_TARGETS_V2+0.070
- MITOTIC_SPINDLE+0.040
- MYOGENESIS+0.040
- APICAL_JUNCTION+0.000
- UV_RESPONSE_DN+0.000
- APICAL_SURFACE-0.010
- SPERMATOGENESIS-0.010
Top 10 suppressed
- MTORC1_SIGNALING-0.610
- OXIDATIVE_PHOSPHORYLATION-0.510
- INTERFERON_GAMMA_RESPONSE-0.500
- MYC_TARGETS_V1-0.500
- IL6_JAK_STAT3_SIGNALING-0.480
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- E2F_TARGETS-0.460
- ANDROGEN_RESPONSE-0.450
- PROTEIN_SECRETION-0.450
- ALLOGRAFT_REJECTION-0.440
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | s0102877 | — | — | 0.955 |
| 2 | TCGA-90-A4ED-01A-31R-A24Z-07 | — | cohortMD1 | 0.927 |
| 3 | AUR-AFE5-TTM9-A-1-1-R-A742-41 | — | D | 0.920 |
| 4 | SRR4195662 | — | — | 0.920 |
| 5 | 302722c6-102e-4b1b-845e-78920380e337 | — | — | 0.917 |
| 6 | SRR1404168 | GTEX | — | 0.915 |
| 7 | ea635e80-1225-4f52-a6cf-8f4c20201240 | — | — | 0.914 |
| 8 | SRR4195673 | — | — | 0.912 |
| 9 | ERR2208935 | — | — | 0.908 |
| 10 | SRR8518450 | — | A | 0.908 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.460 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.190 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.110 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.070 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.040 | Inavolisib | — uncovered |
| MYOGENESIS | 0.040 | Inavolisib | — uncovered |