Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-FD-A3B6-01A-21R-A20F-07

5e6b715d-f698-5d91-a810-18c95eb0f965

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
33.01576873
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.620
  • MYC_TARGETS_V1+0.550
  • E2F_TARGETS+0.530
  • INTERFERON_ALPHA_RESPONSE+0.510
  • ALLOGRAFT_REJECTION+0.500
  • G2M_CHECKPOINT+0.480
  • INTERFERON_GAMMA_RESPONSE+0.460
  • UNFOLDED_PROTEIN_RESPONSE+0.430
  • DNA_REPAIR+0.390
  • MTORC1_SIGNALING+0.380

Top 10 suppressed

  • BILE_ACID_METABOLISM-0.300
  • KRAS_SIGNALING_DN-0.300
  • MYOGENESIS-0.290
  • CHOLESTEROL_HOMEOSTASIS-0.240
  • NOTCH_SIGNALING-0.220
  • WNT_BETA_CATENIN_SIGNALING-0.210
  • HEDGEHOG_SIGNALING-0.170
  • PANCREAS_BETA_CELLS-0.160
  • APICAL_SURFACE-0.150
  • ADIPOGENESIS-0.120

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG1210
mng-umap@100
0.902
2TCGA-BT-A3PJ-01A-21R-A220-07
bladder-landscape@3
0.893
3TCGA-52-7812-01A-11R-2125-07
lung-landscapes@6
cohortA10.892
4TCGA-55-8205-01A-11R-2241-07
lung-landscapes@6
cohortA10.884
5BS_4QW2S1Q8
brain-umap@2
high-grade glioma0.879
6TCGA-PQ-A6FI-01A-11R-A31N-07
bladder-landscape@3
0.877
7SRR934927
brain-umap@2
0.877
8TCGA-GV-A40E-01A-12R-A23N-07
bladder-landscape@3
0.875
9C3N-00203
lung-landscapes@6
cohortA10.874
10TCGA-G2-A2EF-01A-12R-A18C-07
bladder-landscape@3
0.868

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.620Idelalisib— uncovered
MYC_TARGETS_V10.550Inavolisib— uncovered
E2F_TARGETS0.530Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.510Inavolisib— uncovered
ALLOGRAFT_REJECTION0.500Idelalisib— uncovered
G2M_CHECKPOINT0.480Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.460Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.430Idelalisib— uncovered
DNA_REPAIR0.390Idelalisib— uncovered
MTORC1_SIGNALING0.380Inavolisib— uncovered
MITOTIC_SPINDLE0.360Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.340Inavolisib— uncovered
PROTEIN_SECRETION0.320Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.290Idelalisib— uncovered
COMPLEMENT0.240Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.220Inavolisib— uncovered
GLYCOLYSIS0.200Inavolisib— uncovered
TGF_BETA_SIGNALING0.200Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.180Inavolisib— uncovered
UV_RESPONSE_UP0.140Idelalisib— uncovered