SRR8613798
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.490
- WNT_BETA_CATENIN_SIGNALING+0.390
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.310
- UV_RESPONSE_DN+0.290
- NOTCH_SIGNALING+0.270
- TGF_BETA_SIGNALING+0.250
- MITOTIC_SPINDLE+0.230
- ANGIOGENESIS+0.190
- APICAL_JUNCTION+0.190
- MYOGENESIS+0.160
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.620
- INTERFERON_GAMMA_RESPONSE-0.580
- ALLOGRAFT_REJECTION-0.460
- MTORC1_SIGNALING-0.410
- TNFA_SIGNALING_VIA_NFKB-0.410
- CHOLESTEROL_HOMEOSTASIS-0.400
- UV_RESPONSE_UP-0.380
- APOPTOSIS-0.360
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.360
- COMPLEMENT-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8518202 | — | A | 0.867 |
| 2 | TCGA-A1-A0SB-01A-11R-A144-07 | — | A | 0.865 |
| 3 | SRR8613752 | — | A | 0.860 |
| 4 | ERR2208903 | — | — | 0.859 |
| 5 | a9e8922f-fd6c-412d-85f5-40f5ea9b5455 | — | — | 0.848 |
| 6 | SRR6013547 | — | cohortMD1 | 0.843 |
| 7 | TCGA-90-A4ED-01A-31R-A24Z-07 | — | cohortMD1 | 0.843 |
| 8 | TCGA-CQ-7072-01A-21R-A30B-07 | — | — | 0.841 |
| 9 | 20100144.Her2HRpos | — | D | 0.840 |
| 10 | c2bfde36-4ebd-48d7-8662-cf82253a3eab | — | — | 0.833 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.490 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.390 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.310 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.290 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.270 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.250 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.230 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.190 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.190 | Inavolisib | — uncovered |
| MYOGENESIS | 0.160 | Inavolisib | — uncovered |