Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

R426

5f23aad4-12a3-5c91-9579-dfc93fc8dd04

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
5
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.520
  • ALLOGRAFT_REJECTION+0.480
  • IL6_JAK_STAT3_SIGNALING+0.410
  • MYOGENESIS+0.400
  • INTERFERON_GAMMA_RESPONSE+0.370
  • INFLAMMATORY_RESPONSE+0.360
  • HEDGEHOG_SIGNALING+0.310
  • INTERFERON_ALPHA_RESPONSE+0.310
  • KRAS_SIGNALING_UP+0.310
  • APICAL_JUNCTION+0.290

Top 10 suppressed

  • PROTEIN_SECRETION-0.510
  • MYC_TARGETS_V1-0.470
  • OXIDATIVE_PHOSPHORYLATION-0.460
  • MYC_TARGETS_V2-0.380
  • UNFOLDED_PROTEIN_RESPONSE-0.380
  • MTORC1_SIGNALING-0.350
  • TGF_BETA_SIGNALING-0.330
  • ADIPOGENESIS-0.320
  • ANDROGEN_RESPONSE-0.250
  • PI3K_AKT_MTOR_SIGNALING-0.240

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_JT82QGXF
medullo-epn-umap@date-based
MedMedulloblastoma0.932
2R101
bladder-landscape@3
0.928
3BS_2SHWPB5P
brain-umap@2
ganglioneuroblastoma0.927
4MNG1166
mng-umap@100
0.926
5MDT-AP-0380
medullo-epn-umap@date-based
MedMedulloblastoma0.919
6SJEPD029_D.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.919
7SJEPD001535_R2.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.911
8MNG133
mng-umap@100
0.906
9BS_B0SVFK4P
brain-umap@2
pleomorphic xanthoastrocytoma(PXA)0.900
10DRR168569
bladder-landscape@3
0.897