SRR1355040
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.482
- KRAS_SIGNALING_DN+0.363
- PANCREAS_BETA_CELLS+0.284
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.263
- SPERMATOGENESIS+0.257
- MYOGENESIS+0.156
- HEDGEHOG_SIGNALING+0.097
- FATTY_ACID_METABOLISM+0.037
- UV_RESPONSE_UP+0.022
- ESTROGEN_RESPONSE_LATE-0.019
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.542
- TGF_BETA_SIGNALING-0.523
- G2M_CHECKPOINT-0.467
- TNFA_SIGNALING_VIA_NFKB-0.458
- NOTCH_SIGNALING-0.421
- E2F_TARGETS-0.408
- INFLAMMATORY_RESPONSE-0.399
- INTERFERON_GAMMA_RESPONSE-0.382
- ANGIOGENESIS-0.368
- MITOTIC_SPINDLE-0.351
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1387199 | GTEX | — | 0.959 |
| 2 | SRR1416477 | GTEX | — | 0.955 |
| 3 | SRR1414897 | GTEX | — | 0.950 |
| 4 | SRR1474777 | GTEX | — | 0.949 |
| 5 | SRR1435775 | GTEX | — | 0.949 |
| 6 | SRR1408208 | GTEX | — | 0.944 |
| 7 | SRR1435020 | GTEX | — | 0.944 |
| 8 | SRR1360563 | GTEX | — | 0.943 |
| 9 | SRR810877 | GTEX | — | 0.942 |
| 10 | SRR1452379 | GTEX | — | 0.939 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.482 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.363 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.284 | Cobimetinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.263 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.257 | Inavolisib | — uncovered |
| MYOGENESIS | 0.156 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.097 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.037 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.022 | Idelalisib | — uncovered |