Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

B99430AD-6309-4B90-A0AA-A5B2FA746246

6303b015-daa5-50bb-989c-75bf540900de

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
7.851511169513797
age_years
59
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1FFECD0E9-70C2-44BD-B0B4-E8C4B60B793A
brain-umap@2
0.959
28DA59514-8B25-493E-B226-818F2521B5D5
brain-umap@2
0.957
3CC9815B3-88D0-4376-B96F-B979E1FBD0C7
brain-umap@2
0.956
4SRR934883
brain-umap@2
0.955
5E24D233D-71BD-4EC2-A671-375917F24E5C
brain-umap@2
0.954
6EC1C727A-1F71-4C09-B867-7F163424D463
brain-umap@2
0.953
7E00A399D-E6C3-439D-8E70-A7AD5DF5F5E2
brain-umap@2
0.952
8A2170829-B80C-49F2-8FB6-39B8ACFB27CB
brain-umap@2
0.950
9541FDA8B-9FAE-4346-A6FD-C56735C87920
brain-umap@2
0.948
10E7BE221B-273D-4C04-BE79-366E6455EFBC
brain-umap@2
0.945

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.563Inavolisib— uncovered
ANGIOGENESIS0.554Remibrutinib— uncovered
MYC_TARGETS_V10.540Inavolisib— uncovered
DNA_REPAIR0.527Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.514Remibrutinib— uncovered
G2M_CHECKPOINT0.452Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.439Inavolisib— uncovered
MYC_TARGETS_V20.427Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.419Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.415Inavolisib— uncovered
ALLOGRAFT_REJECTION0.411Idelalisib— uncovered
GLYCOLYSIS0.410Inavolisib— uncovered
APOPTOSIS0.408Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.397Inavolisib— uncovered
MTORC1_SIGNALING0.393Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.385Inavolisib— uncovered
HYPOXIA0.383Idelalisib— uncovered
NOTCH_SIGNALING0.383Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.373Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.361Idelalisib— uncovered