MBCProject_3717_T3_RNA
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.610
- E2F_TARGETS+0.510
- MYC_TARGETS_V1+0.440
- G2M_CHECKPOINT+0.360
- MTORC1_SIGNALING+0.330
- OXIDATIVE_PHOSPHORYLATION+0.330
- SPERMATOGENESIS+0.300
- UNFOLDED_PROTEIN_RESPONSE+0.290
- DNA_REPAIR+0.250
- UV_RESPONSE_UP+0.200
Top 10 suppressed
- UV_RESPONSE_DN-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
- TGF_BETA_SIGNALING-0.410
- TNFA_SIGNALING_VIA_NFKB-0.390
- NOTCH_SIGNALING-0.350
- COAGULATION-0.340
- BILE_ACID_METABOLISM-0.320
- APOPTOSIS-0.310
- ANDROGEN_RESPONSE-0.300
- KRAS_SIGNALING_UP-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-63-7023-01A-11R-1949-07 | — | cohortSQ2 | 0.882 |
| 2 | TCGA-22-5481-01A-31R-1949-07 | — | cohortMD1 | 0.863 |
| 3 | SRR15030859 | — | — | 0.863 |
| 4 | ERR2208932 | — | — | 0.859 |
| 5 | AUR-AG0N-TTM1-A-1-1-R-A743-41 | — | E | 0.856 |
| 6 | TCGA-E7-A85H-01A-11R-A352-07 | — | — | 0.855 |
| 7 | 504282dd-4fef-4f70-a709-6a545d00a263 | — | — | 0.854 |
| 8 | TCGA-HN-A2NL-01A-11R-A18M-07 | — | E | 0.853 |
| 9 | 085e4228-8ed7-44d7-9ab5-8a096434b650 | — | — | 0.851 |
| 10 | TCGA-34-5231-01A-21R-1820-07 | — | cohortSQ2 | 0.847 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.610 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.510 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.440 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.360 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.330 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.330 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.300 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.290 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.250 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.200 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.140 | Cobimetinib | — uncovered |
| GLYCOLYSIS | 0.090 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.040 | Remibrutinib | — uncovered |