Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

cf9ea065-c101-48e2-a1ea-54eb01658eef

653b8c17-6d88-5ac0-a3e0-f9b8de078324

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-02923
lung-landscapes@6
cohortMD20.938
2TCGA-CR-7376-01A-11R-2132-07
head-neck@1
0.926
3TCGA-55-8299-01A-11R-2287-07
lung-landscapes@6
cohortMD20.925
4MDT-AP-3277
medullo-epn-umap@date-based
MedMedulloblastoma0.920
5b02dc7a2-3615-4b6c-a3dd-a866d8561d9d
colon-landscapes@1
0.919
66dfa748c-af43-469f-a98b-8472a4132739
melanoma-umap@29
0.917
7c277dab0-361f-4aa6-96b1-522a6e556ae1
colon-landscapes@1
0.911
8TCGA-D8-A141-01A-11R-A115-07
breast-umap@18
A0.907
9d53d6bb4.fa4d.4fb5.abcb.208af064f719
lung-landscapes@6
cohortMD20.907
10ERR2208918
melanoma-umap@29
0.904

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.500Idelalisib— uncovered
ANGIOGENESIS0.500Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.500Inavolisib— uncovered
COMPLEMENT0.400Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.400Inavolisib— uncovered
IL2_STAT5_SIGNALING0.400Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.400Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.400Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.400Idelalisib— uncovered
KRAS_SIGNALING_UP0.400Inavolisib— uncovered
TGF_BETA_SIGNALING0.400Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.300Inavolisib— uncovered
UV_RESPONSE_DN0.300Inavolisib— uncovered
APICAL_SURFACE0.200Temsirolimus— uncovered
APOPTOSIS0.200Idelalisib— uncovered
COAGULATION0.200Binimetinib— uncovered
NOTCH_SIGNALING0.200Inavolisib— uncovered
ANDROGEN_RESPONSE0.100Inavolisib— uncovered
APICAL_JUNCTION0.100Inavolisib— uncovered
BILE_ACID_METABOLISM0.100Inavolisib— uncovered