Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

ERR2278877

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65583a5e-86ce-586c-9fc2-ec81f7625ceb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.650
  • INTERFERON_GAMMA_RESPONSE+0.570
  • TNFA_SIGNALING_VIA_NFKB+0.500
  • MYC_TARGETS_V2+0.470
  • IL6_JAK_STAT3_SIGNALING+0.360
  • INFLAMMATORY_RESPONSE+0.320
  • ALLOGRAFT_REJECTION+0.310
  • P53_PATHWAY+0.260
  • COMPLEMENT+0.250
  • CHOLESTEROL_HOMEOSTASIS+0.240

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.360
  • ANGIOGENESIS-0.200
  • BILE_ACID_METABOLISM-0.180
  • KRAS_SIGNALING_UP-0.180
  • ANDROGEN_RESPONSE-0.160
  • MYOGENESIS-0.140
  • OXIDATIVE_PHOSPHORYLATION-0.140
  • PANCREAS_BETA_CELLS-0.120
  • HEDGEHOG_SIGNALING-0.110
  • NOTCH_SIGNALING-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2278874
head-neck@1
——0.873
220080189.TNBC
breast-umap@18
—E0.817
3TCGA-CV-7089-01A-11R-2016-07
head-neck@1
——0.806
4TCGA-E7-A7XN-01A-11R-A352-07
bladder-landscape@3
——0.804
5SRR27320692
colon-landscapes@1
——0.801
6s0112313
melanoma-umap@29
——0.798
7s0099965
melanoma-umap@29
——0.797
8TCGA-XF-A8HE-01A-11R-A36F-07
bladder-landscape@3
——0.794
9BS_M7HCF7DW
brain-umap@2
high-grade glioma—0.793
10TCGA-G2-A2EJ-01A-11R-A180-07
bladder-landscape@3
——0.785

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.650Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.570Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.500Inavolisib— uncovered
MYC_TARGETS_V20.470Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.360Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.320Idelalisib— uncovered
ALLOGRAFT_REJECTION0.310Idelalisib— uncovered
P53_PATHWAY0.260Idelalisib— uncovered
COMPLEMENT0.250Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.240Remibrutinib— uncovered
APICAL_SURFACE0.230Temsirolimus— uncovered
E2F_TARGETS0.220Inavolisib— uncovered
G2M_CHECKPOINT0.220Inavolisib— uncovered
MITOTIC_SPINDLE0.190Inavolisib— uncovered
UV_RESPONSE_UP0.190Idelalisib— uncovered
APOPTOSIS0.170Idelalisib— uncovered
MTORC1_SIGNALING0.170Inavolisib— uncovered
MYC_TARGETS_V10.170Inavolisib— uncovered
APICAL_JUNCTION0.160Inavolisib— uncovered
IL2_STAT5_SIGNALING0.130Idelalisib— uncovered