Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG1207

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68ad84fc-ac9d-5882-8d65-11f7f2da61df

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.468
  • MTORC1_SIGNALING+0.389
  • MYC_TARGETS_V1+0.389
  • PROTEIN_SECRETION+0.349
  • UNFOLDED_PROTEIN_RESPONSE+0.323
  • GLYCOLYSIS+0.230
  • ANGIOGENESIS+0.218
  • MYC_TARGETS_V2+0.197
  • TNFA_SIGNALING_VIA_NFKB+0.193
  • P53_PATHWAY+0.191

Top 10 suppressed

  • NOTCH_SIGNALING-0.359
  • MITOTIC_SPINDLE-0.325
  • INTERFERON_ALPHA_RESPONSE-0.281
  • HEDGEHOG_SIGNALING-0.275
  • MYOGENESIS-0.254
  • APICAL_SURFACE-0.240
  • UV_RESPONSE_DN-0.206
  • WNT_BETA_CATENIN_SIGNALING-0.196
  • APICAL_JUNCTION-0.183
  • KRAS_SIGNALING_DN-0.176

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-BA-4075-01A-01R-1436-07
head-neck@1
——0.834
2TCGA-66-2778-01A-02R-0851-07
lung-landscapes@6
—cohortSQ10.754
3TCGA-46-3765-01A-01R-0980-07
lung-landscapes@6
—cohortSQ20.752
452606_S129
lung-landscapes@6
—cohortA40.712
5SRR10842375
melanoma-umap@29
——0.711
6bf93be3e-d4f1-4efb-9841-ca8ad81b237e
colon-landscapes@1
——0.700
7fd17af6d-f9d4-4d4f-8487-bf8b97cfe3ab
colon-landscapes@1
——0.697
8SRR13311171
bladder-landscape@3
——0.692
9TCGA-BA-4074-01A-01R-1436-07
head-neck@1
——0.688
10be22f883.ee5e.4632.93d1.661ddc53608e
lung-landscapes@6
—cohortA40.681

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.468Remibrutinib— uncovered
MTORC1_SIGNALING0.389Inavolisib— uncovered
MYC_TARGETS_V10.389Inavolisib— uncovered
PROTEIN_SECRETION0.349Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.323Idelalisib— uncovered
GLYCOLYSIS0.230Inavolisib— uncovered
ANGIOGENESIS0.218Remibrutinib— uncovered
MYC_TARGETS_V20.197Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.193Inavolisib— uncovered
P53_PATHWAY0.191Idelalisib— uncovered
COAGULATION0.172Binimetinib— uncovered
ANDROGEN_RESPONSE0.167Inavolisib— uncovered
PANCREAS_BETA_CELLS0.152Cobimetinib— uncovered
HYPOXIA0.140Idelalisib— uncovered
COMPLEMENT0.126Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.120Inavolisib— uncovered
FATTY_ACID_METABOLISM0.119Inavolisib— uncovered
DNA_REPAIR0.114Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.103Inavolisib— uncovered
UV_RESPONSE_UP0.101Idelalisib— uncovered