TCGA-55-8097-01A-11R-2241-07
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 60
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR6013544 | — | cohortA1 | 0.921 |
| 2 | C3L-00893 | — | cohortA1 | 0.911 |
| 3 | C3N-00293 | — | cohortA1 | 0.911 |
| 4 | TCGA-69-7764-01A-11R-2170-07 | — | cohortA2 | 0.897 |
| 5 | TCGA-55-8087-01A-11R-2241-07 | — | cohortA1 | 0.890 |
| 6 | TCGA-73-7498-01A-12R-2187-07 | — | cohortA2 | 0.884 |
| 7 | C3N-01409 | — | cohortA1 | 0.884 |
| 8 | C3L-00444 | — | cohortA1 | 0.881 |
| 9 | SRR1516060 | — | — | 0.874 |
| 10 | TCGA-D8-A4Z1-01A-21R-A266-07 | — | A | 0.874 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.320 | Inavolisib | — uncovered |
| MYOGENESIS | 0.200 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.190 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.150 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.120 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.110 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.080 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.030 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.010 | Inavolisib | — uncovered |