Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_5PEFNDCY

Glial-neuronal tumor NOS

6c14a8eb-21d2-58e6-a3de-95166ebd43f9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Glial-neuronal tumor NOS
cancer_type_detailed
subtype
cancer_type
Glial-neuronal tumor NOS
age_years
7.822
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.426
  • PANCREAS_BETA_CELLS+0.369
  • MYOGENESIS+0.335
  • APICAL_SURFACE+0.314
  • COAGULATION+0.275
  • INTERFERON_ALPHA_RESPONSE+0.269
  • KRAS_SIGNALING_UP+0.209
  • INFLAMMATORY_RESPONSE+0.203
  • BILE_ACID_METABOLISM+0.198
  • XENOBIOTIC_METABOLISM+0.160

Top 10 suppressed

  • MYC_TARGETS_V1-0.661
  • MYC_TARGETS_V2-0.653
  • E2F_TARGETS-0.605
  • OXIDATIVE_PHOSPHORYLATION-0.578
  • G2M_CHECKPOINT-0.560
  • DNA_REPAIR-0.555
  • UNFOLDED_PROTEIN_RESPONSE-0.528
  • WNT_BETA_CATENIN_SIGNALING-0.382
  • MTORC1_SIGNALING-0.371
  • MITOTIC_SPINDLE-0.369

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

1 twin match this tumor's tissue · 9 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_1ZVXF5FE
brain-umap@2
pilocytic astrocytoma0.941
2BS_Y7F9E2E9
brain-umap@2
low-grade glioma0.926
3BS_398KYV92
brain-umap@2
Meningioma0.922
4MDT-AP-0208
medullo-epn-umap@date-based
MedMedulloblastoma0.921
5s_150324_2b
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.914
6MNG613
mng-umap@100
0.913
7SRR1417202
brain-umap@2
GTEX0.906
8SRR1440962
brain-umap@2
GTEX0.905
9BS_912NX4Y0
brain-umap@2
Ganglioglioma0.904
10SRR1338627
brain-umap@2
GTEX0.903

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.426Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.369Cobimetinib— uncovered
MYOGENESIS0.335Inavolisib— uncovered
APICAL_SURFACE0.314Temsirolimus— uncovered
COAGULATION0.275Binimetinib— uncovered
INTERFERON_ALPHA_RESPONSE0.269Inavolisib— uncovered
KRAS_SIGNALING_UP0.209Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.203Idelalisib— uncovered
BILE_ACID_METABOLISM0.198Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.160Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.148Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.140Inavolisib— uncovered
HEDGEHOG_SIGNALING0.131Inavolisib— uncovered
SPERMATOGENESIS0.123Inavolisib— uncovered
ALLOGRAFT_REJECTION0.095Idelalisib— uncovered
UV_RESPONSE_DN0.083Inavolisib— uncovered
ANDROGEN_RESPONSE0.082Inavolisib— uncovered
COMPLEMENT0.080Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.072Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.059Remibrutinib— uncovered