Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

6410821A-1C6A-4F64-939F-196313B8F1E5

6c6f9e94-e71f-535a-a283-39880b1da8b7

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
14.914586070959263
age_years
60
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AB5294B5-4A59-493A-9016-C2778735745F
brain-umap@2
0.977
293708EED-CBE1-4B2E-A571-34316ACFE748
brain-umap@2
0.974
3AF548E30-7121-4F9F-A2CD-F1A540E9C4EE
brain-umap@2
0.972
4E89DB941-19C3-4CD9-9117-EAAF3B2AFD76
brain-umap@2
0.967
5CC9815B3-88D0-4376-B96F-B979E1FBD0C7
brain-umap@2
0.965
6A2170829-B80C-49F2-8FB6-39B8ACFB27CB
brain-umap@2
0.965
7E7BE221B-273D-4C04-BE79-366E6455EFBC
brain-umap@2
0.963
897A8E2B1-059B-4527-8FB4-116F718FFD16
brain-umap@2
0.957
9DF145DF3-D7FD-48C9-ADC8-0B8618DC65A8
brain-umap@2
0.956
10BB96C5BA-CA50-40B4-B22A-3FCFE46AB11C
brain-umap@2
0.955

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.606Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.592Remibrutinib— uncovered
E2F_TARGETS0.559Inavolisib— uncovered
DNA_REPAIR0.523Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.504Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.477Idelalisib— uncovered
ALLOGRAFT_REJECTION0.458Idelalisib— uncovered
MYC_TARGETS_V20.453Idelalisib— uncovered
MTORC1_SIGNALING0.434Inavolisib— uncovered
G2M_CHECKPOINT0.422Inavolisib— uncovered
ANGIOGENESIS0.406Remibrutinib— uncovered
ADIPOGENESIS0.396Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.392Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.388Idelalisib— uncovered
APOPTOSIS0.382Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.373Inavolisib— uncovered
COMPLEMENT0.357Inavolisib— uncovered
FATTY_ACID_METABOLISM0.354Inavolisib— uncovered
GLYCOLYSIS0.349Inavolisib— uncovered
P53_PATHWAY0.316Idelalisib— uncovered