SRR6013553
— · cohortA3
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA3
- subtype
- cohortA3
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.450
- E2F_TARGETS+0.370
- MITOTIC_SPINDLE+0.360
- G2M_CHECKPOINT+0.350
- HEDGEHOG_SIGNALING+0.160
- INTERFERON_GAMMA_RESPONSE+0.160
- NOTCH_SIGNALING+0.130
- SPERMATOGENESIS+0.050
- WNT_BETA_CATENIN_SIGNALING+0.030
- UV_RESPONSE_DN+0.020
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.510
- ALLOGRAFT_REJECTION-0.430
- OXIDATIVE_PHOSPHORYLATION-0.430
- INFLAMMATORY_RESPONSE-0.420
- TNFA_SIGNALING_VIA_NFKB-0.410
- MTORC1_SIGNALING-0.390
- PROTEIN_SECRETION-0.390
- HYPOXIA-0.380
- UV_RESPONSE_UP-0.380
- ADIPOGENESIS-0.370
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCproject_6016_T1_RNA | — | A | 0.880 |
| 2 | MNG357 | — | — | 0.871 |
| 3 | TCGA-91-6840-01A-11R-1949-07 | — | cohortA1 | 0.860 |
| 4 | SRR1313133 | — | D | 0.848 |
| 5 | SRR8613722 | — | E | 0.848 |
| 6 | BS_9FHSNVS0 | ATRT | — | 0.845 |
| 7 | MNG790 | — | — | 0.820 |
| 8 | SRR4195665 | — | — | 0.817 |
| 9 | 83486 | EPN | Supratentorial EPN | 0.817 |
| 10 | TCGA-50-5946-01A-11R-1755-07 | — | cohortA1 | 0.816 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.450 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.370 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.360 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.350 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.160 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.160 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.130 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.050 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.030 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.020 | Inavolisib | — uncovered |