Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AR-A1AL-01A-21R-A12P-07

· A

6dc5b6b8-9a2d-572d-a222-a0b8a0f9a444

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
99

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AR-A2LM-01A-11R-A180-07
breast-umap@18
A0.935
2MBCProject_3896_T1_RNA
breast-umap@18
A0.911
3SRR8613708
breast-umap@18
A0.888
4TCGA-A2-A0YL-01A-21R-A109-07
breast-umap@18
A0.880
5TCGA-BH-A1FH-01A-12R-A13Q-07
breast-umap@18
A0.877
6TCGA-E2-A1IO-01A-11R-A144-07
breast-umap@18
A0.876
7TCGA-D8-A27L-01A-11R-A16F-07
breast-umap@18
A0.875
8TCGA-BH-A0H3-01A-11R-A12P-07
breast-umap@18
A0.873
9023160e4-1d9a-499c-9bfa-1b3aacf284f2
colon-landscapes@1
0.861
10TCGA-EW-A1IX-01A-12R-A144-07
breast-umap@18
A0.857

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.500Inavolisib— uncovered
TGF_BETA_SIGNALING0.350Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.350Inavolisib— uncovered
HEDGEHOG_SIGNALING0.300Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.260Inavolisib— uncovered
KRAS_SIGNALING_UP0.260Inavolisib— uncovered
MITOTIC_SPINDLE0.240Inavolisib— uncovered
APICAL_JUNCTION0.230Inavolisib— uncovered
MYOGENESIS0.200Inavolisib— uncovered
NOTCH_SIGNALING0.200Inavolisib— uncovered
ANGIOGENESIS0.190Remibrutinib— uncovered
APICAL_SURFACE0.190Temsirolimus— uncovered
IL6_JAK_STAT3_SIGNALING0.170Inavolisib— uncovered
APOPTOSIS0.140Idelalisib— uncovered
IL2_STAT5_SIGNALING0.140Idelalisib— uncovered
ANDROGEN_RESPONSE0.130Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.130Idelalisib— uncovered
PROTEIN_SECRETION0.100Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.090Inavolisib— uncovered
HYPOXIA0.070Idelalisib— uncovered