SRR608574
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.262
- PANCREAS_BETA_CELLS+0.226
- PEROXISOME+0.203
- KRAS_SIGNALING_DN+0.175
- HEDGEHOG_SIGNALING+0.148
- SPERMATOGENESIS+0.128
- OXIDATIVE_PHOSPHORYLATION+0.124
- BILE_ACID_METABOLISM+0.116
- PROTEIN_SECRETION+0.096
- APICAL_JUNCTION+0.094
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.400
- G2M_CHECKPOINT-0.376
- TGF_BETA_SIGNALING-0.372
- MYC_TARGETS_V2-0.362
- NOTCH_SIGNALING-0.359
- E2F_TARGETS-0.324
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.295
- MYC_TARGETS_V1-0.291
- UV_RESPONSE_DN-0.265
- MITOTIC_SPINDLE-0.252
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1467455 | GTEX | — | 0.877 |
| 2 | SRR1354013 | GTEX | — | 0.836 |
| 3 | SRR604050 | GTEX | — | 0.830 |
| 4 | SRR1446092 | GTEX | — | 0.828 |
| 5 | SRR665502 | GTEX | — | 0.824 |
| 6 | SRR1317596 | GTEX | — | 0.817 |
| 7 | SRR1319970 | GTEX | — | 0.807 |
| 8 | SRR1401276 | GTEX | — | 0.806 |
| 9 | MDT-AP-2024 | Med | Medulloblastoma | 0.802 |
| 10 | SRR600361 | GTEX | — | 0.800 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 17 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.262 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.226 | Cobimetinib | — uncovered |
| PEROXISOME | 0.203 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.175 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.148 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.128 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.124 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.116 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.096 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.094 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.093 | Temsirolimus | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.091 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.079 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.078 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.058 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.035 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.003 | Inavolisib | — uncovered |