Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-G2-A2EK-01A-22R-A18C-07

71af7e6d-9ec3-5640-8be1-168d909a86f3

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
15.93298292
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.380
  • BILE_ACID_METABOLISM+0.280
  • APICAL_SURFACE+0.230
  • COAGULATION+0.200
  • ESTROGEN_RESPONSE_EARLY+0.190
  • MYOGENESIS+0.180
  • PANCREAS_BETA_CELLS+0.160
  • KRAS_SIGNALING_UP+0.140
  • ESTROGEN_RESPONSE_LATE+0.100
  • XENOBIOTIC_METABOLISM+0.070

Top 10 suppressed

  • E2F_TARGETS-0.650
  • MYC_TARGETS_V1-0.630
  • MYC_TARGETS_V2-0.630
  • G2M_CHECKPOINT-0.620
  • MTORC1_SIGNALING-0.530
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.530
  • DNA_REPAIR-0.510
  • OXIDATIVE_PHOSPHORYLATION-0.510
  • UNFOLDED_PROTEIN_RESPONSE-0.490
  • MITOTIC_SPINDLE-0.460

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1TCGA-97-8552-01A-11R-2403-07
lung-landscapes@6
cohortA10.938
2BS_063ERW0R
brain-umap@2
pilocytic astrocytoma0.934
3TCGA-XF-A9SH-01A-11R-A39I-07
bladder-landscape@3
0.921
4BS_C80S5N37
medullo-epn-umap@date-based
EPNEPN Tumor0.915
5BS_JXNZYGCR
brain-umap@2
DNET0.914
6BS_K5802F84
brain-umap@2
pilocytic astrocytoma0.912
7TCGA-55-8616-01A-11R-2403-07
lung-landscapes@6
cohortA10.911
8BS_9F09XV62
brain-umap@2
low-grade glioma0.909
9BS_CQSAJ7BF
brain-umap@2
DNET0.909
10TCGA-97-A4M1-01A-11R-A24X-07
lung-landscapes@6
cohortA10.908

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 11 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.380Remibrutinib— uncovered
BILE_ACID_METABOLISM0.280Inavolisib— uncovered
APICAL_SURFACE0.230Temsirolimus— uncovered
COAGULATION0.200Binimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.190Inavolisib— uncovered
MYOGENESIS0.180Inavolisib— uncovered
PANCREAS_BETA_CELLS0.160Cobimetinib— uncovered
KRAS_SIGNALING_UP0.140Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.100Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.070Inavolisib— uncovered
NOTCH_SIGNALING0.040Inavolisib— uncovered