SRR1339740
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.344
- PANCREAS_BETA_CELLS+0.260
- MYOGENESIS+0.221
- CHOLESTEROL_HOMEOSTASIS+0.213
- SPERMATOGENESIS+0.210
- APICAL_JUNCTION+0.106
- APICAL_SURFACE+0.048
- HEDGEHOG_SIGNALING+0.028
- ESTROGEN_RESPONSE_LATE-0.014
- KRAS_SIGNALING_UP-0.038
Top 10 suppressed
- MYC_TARGETS_V2-0.499
- MYC_TARGETS_V1-0.448
- UNFOLDED_PROTEIN_RESPONSE-0.444
- G2M_CHECKPOINT-0.441
- E2F_TARGETS-0.424
- TNFA_SIGNALING_VIA_NFKB-0.380
- NOTCH_SIGNALING-0.368
- DNA_REPAIR-0.348
- HYPOXIA-0.337
- MTORC1_SIGNALING-0.337
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_063ERW0R | pilocytic astrocytoma | — | 0.940 |
| 2 | BS_2XD3MNKD | Glial-neuronal tumor NOS | — | 0.932 |
| 3 | SRR1358501 | GTEX | — | 0.916 |
| 4 | SRR1325986 | GTEX | — | 0.915 |
| 5 | BS_QC3XCE6X | low-grade glioma | — | 0.913 |
| 6 | SRR1357021 | GTEX | — | 0.910 |
| 7 | SRR821581 | GTEX | — | 0.909 |
| 8 | BS_CQSAJ7BF | DNET | — | 0.907 |
| 9 | BS_K5802F84 | pilocytic astrocytoma | — | 0.907 |
| 10 | SRR657891 | GTEX | — | 0.907 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.344 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.260 | Cobimetinib | — uncovered |
| MYOGENESIS | 0.221 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.213 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.210 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.106 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.048 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.028 | Inavolisib | — uncovered |