Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-E7-A97P-01A-11R-A38B-07

732c9ecd-54a3-5859-8afe-6f254c83baa5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
14.35611038
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.740
  • INTERFERON_GAMMA_RESPONSE+0.650
  • ALLOGRAFT_REJECTION+0.580
  • IL6_JAK_STAT3_SIGNALING+0.510
  • INFLAMMATORY_RESPONSE+0.490
  • TGF_BETA_SIGNALING+0.490
  • PROTEIN_SECRETION+0.480
  • COMPLEMENT+0.470
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.460
  • TNFA_SIGNALING_VIA_NFKB+0.460

Top 10 suppressed

  • SPERMATOGENESIS-0.210
  • KRAS_SIGNALING_DN-0.180
  • PANCREAS_BETA_CELLS-0.150
  • BILE_ACID_METABOLISM-0.080
  • MYOGENESIS+0.020
  • XENOBIOTIC_METABOLISM+0.040
  • ADIPOGENESIS+0.050
  • FATTY_ACID_METABOLISM+0.100
  • HEME_METABOLISM+0.100
  • UV_RESPONSE_UP+0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934750
brain-umap@2
0.956
2DB34442C-1882-495A-A2F0-2427116A1FAF
brain-umap@2
0.953
32D0A1BA3-EC1D-4B4F-A383-9353C0F4BE85
brain-umap@2
0.951
4E9FC1686-028B-476C-B51B-4956213D874B
brain-umap@2
0.950
5C13F6AB6-41C0-4F51-A240-BA4F4410B68E
brain-umap@2
0.950
6795FBB8C-0E74-477F-AA27-1CE97A4E90B9
brain-umap@2
0.948
7C6A60028-2402-4048-90DF-F2B3712FB530
brain-umap@2
0.946
8SRR934782
brain-umap@2
0.946
9A678E1E5-E02D-49A1-BB2B-C91A60E6382E
brain-umap@2
0.942
10SRR934921
brain-umap@2
0.941

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 46 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.740Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.650Idelalisib— uncovered
ALLOGRAFT_REJECTION0.580Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.510Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.490Idelalisib— uncovered
TGF_BETA_SIGNALING0.490Inavolisib— uncovered
PROTEIN_SECRETION0.480Remibrutinib— uncovered
COMPLEMENT0.470Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.460Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.460Inavolisib— uncovered
G2M_CHECKPOINT0.450Inavolisib— uncovered
COAGULATION0.440Binimetinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.440Inavolisib— uncovered
MYC_TARGETS_V10.430Inavolisib— uncovered
APOPTOSIS0.400Idelalisib— uncovered
E2F_TARGETS0.390Inavolisib— uncovered
MITOTIC_SPINDLE0.380Inavolisib— uncovered
MTORC1_SIGNALING0.380Inavolisib— uncovered
ANDROGEN_RESPONSE0.370Inavolisib— uncovered
IL2_STAT5_SIGNALING0.370Idelalisib— uncovered