Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG1056

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7334ab4d-9620-5e12-a669-6d9177a74265

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.534
  • PEROXISOME+0.374
  • ANDROGEN_RESPONSE+0.320
  • HEME_METABOLISM+0.293
  • BILE_ACID_METABOLISM+0.277
  • HEDGEHOG_SIGNALING+0.243
  • UV_RESPONSE_DN+0.238
  • TGF_BETA_SIGNALING+0.234
  • CHOLESTEROL_HOMEOSTASIS+0.231
  • OXIDATIVE_PHOSPHORYLATION+0.229

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.503
  • IL6_JAK_STAT3_SIGNALING-0.428
  • INTERFERON_GAMMA_RESPONSE-0.399
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.370
  • INFLAMMATORY_RESPONSE-0.368
  • INTERFERON_ALPHA_RESPONSE-0.366
  • E2F_TARGETS-0.304
  • TNFA_SIGNALING_VIA_NFKB-0.281
  • KRAS_SIGNALING_UP-0.243
  • PANCREAS_BETA_CELLS-0.242

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
11D3FBEA0-9A7F-436C-AA71-366D4E11C43B
brain-umap@2
——0.902
2MNG677
mng-umap@100
——0.897
3TCGA-BH-A0BS-01A-11R-A12P-07
breast-umap@18
—B0.874
4MNG1024
mng-umap@100
——0.844
5D155B4CA-927F-4B4F-B6BC-2D41267F195E
brain-umap@2
——0.837
63DC38276-A6D2-49C6-8F54-3F50F6BFAD0C
brain-umap@2
——0.833
7MNG1034
mng-umap@100
——0.826
8SJEPD031010_D1.RNA-Seq
medullo-epn-umap@date-based
EPNEPN Tumor0.821
902F669D8-FB9F-45AF-A999-5886E5C2DAF0
brain-umap@2
——0.812
10MNG1176
mng-umap@100
——0.802

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.534Remibrutinib— uncovered
PEROXISOME0.374Idelalisib— uncovered
ANDROGEN_RESPONSE0.320Inavolisib— uncovered
HEME_METABOLISM0.293Temsirolimus— uncovered
BILE_ACID_METABOLISM0.277Inavolisib— uncovered
HEDGEHOG_SIGNALING0.243Inavolisib— uncovered
UV_RESPONSE_DN0.238Inavolisib— uncovered
TGF_BETA_SIGNALING0.234Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.231Remibrutinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.229Remibrutinib— uncovered
MITOTIC_SPINDLE0.221Inavolisib— uncovered
ADIPOGENESIS0.201Inavolisib— uncovered
NOTCH_SIGNALING0.197Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.142Idelalisib— uncovered
MTORC1_SIGNALING0.134Inavolisib— uncovered
FATTY_ACID_METABOLISM0.120Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.097Inavolisib— uncovered
MYC_TARGETS_V10.083Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.066Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.059Inavolisib— uncovered