BS_30VC3R2Q
Diffuse intrinsic pontine glioma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Diffuse intrinsic pontine glioma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- Diffuse intrinsic pontine glioma
- overall_survival_months
- 32.95006570302234
- age_years
- 2.932
- sex
- Female
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R275 | — | — | 0.849 |
| 2 | TCGA-77-7338-01A-11R-2045-07 | — | cohortSQ2 | 0.847 |
| 3 | 2DAB6792-F9AF-4565-BDD5-C9802F3132F4 | — | — | 0.842 |
| 4 | 8D30F824-25B9-43DB-BD39-2C9C790509DD | — | — | 0.840 |
| 5 | TCGA-66-2734-01A-01R-0980-07 | — | cohortSQ1 | 0.834 |
| 6 | SRR2932816 | — | — | 0.826 |
| 7 | BS_VP3C8WZT | pilocytic astrocytoma | — | 0.821 |
| 8 | BS_2YCJV2VV | low-grade glioma | — | 0.820 |
| 9 | SRR1313161 | — | C | 0.817 |
| 10 | TCGA-77-7337-01A-21R-2045-07 | — | cohortSQ1 | 0.814 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 42 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.516 | Remibrutinib | — uncovered |
| HYPOXIA | 0.506 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.454 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.435 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.414 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.405 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.390 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.389 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.383 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.370 | Remibrutinib | — uncovered |
| GLYCOLYSIS | 0.356 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.350 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.348 | Inavolisib | — uncovered |
| APOPTOSIS | 0.334 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.328 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.320 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.319 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.299 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.289 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.281 | Inavolisib | — uncovered |