R317

—

76add764-39f8-5d2d-961e-38d09dae80f2

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —
overall_survival_months: 71
sex: Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-FD-A62N-01A-11R-A30C-07 bladder-landscape@3	—	—	0.892
2	SRR4296104 lung-landscapes@6	—	cohortA1	0.891
3	AUR-AFUI-TTP1-A-1-0-R-A743-41 breast-umap@18	—	C	0.888
4	BS_3J85TTZM brain-umap@2	MPNST	—	0.883
5	R303 bladder-landscape@3	—	—	0.882
6	SRR1516078 bladder-landscape@3	—	—	0.878
7	20050099.TNBC breast-umap@18	—	D	0.877
8	TCGA-63-A5MM-01A-11R-A26W-07 lung-landscapes@6	—	cohortA1	0.877
9	SRR8943031 bladder-landscape@3	—	—	0.875
10	TCGA-BT-A3PK-01A-21R-A220-07 bladder-landscape@3	—	—	0.874

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 36 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
INTERFERON_ALPHA_RESPONSE	0.690	Inavolisib	— uncovered
ALLOGRAFT_REJECTION	0.620	Idelalisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.620	Idelalisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.590	Inavolisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.590	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.580	Idelalisib	— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION	0.490	Inavolisib	— uncovered
COMPLEMENT	0.420	Inavolisib	— uncovered
ANGIOGENESIS	0.410	Remibrutinib	— uncovered
E2F_TARGETS	0.410	Inavolisib	— uncovered
IL2_STAT5_SIGNALING	0.390	Idelalisib	— uncovered
COAGULATION	0.370	Binimetinib	— uncovered
KRAS_SIGNALING_UP	0.360	Inavolisib	— uncovered
APOPTOSIS	0.340	Idelalisib	— uncovered
APICAL_JUNCTION	0.320	Inavolisib	— uncovered
G2M_CHECKPOINT	0.320	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.310	Remibrutinib	— uncovered
P53_PATHWAY	0.310	Idelalisib	— uncovered
HYPOXIA	0.280	Idelalisib	— uncovered
UV_RESPONSE_UP	0.280	Idelalisib	— uncovered