Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

DE370889-1057-4355-AFD8-CCFCDC6CD00F

76df1d83-8944-5de1-aefd-70fa56869166

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
27.201051248357423
age_years
69
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

HTTPException: HTTP Error: HTTP GET error on 'https://pub-e056b053afc04eec88337b62541f3025.r2.dev/oncoscape/brain-umap/2/gsva.parquet' (HTTP 429 Too Many Requests)

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
17876A884-F031-42AB-ADC0-89589760FB6B
brain-umap@2
0.981
20E66EFB0-712B-4A52-8F75-A37F030CABEF
brain-umap@2
0.979
366FF1C46-83F0-4EEC-9871-448C8C7EA3AE
brain-umap@2
0.977
4DD203D19-D635-4112-AF75-9724E0A64A0B
brain-umap@2
0.977
5A9B59C46-7F32-4DD1-9649-B1788CA5E909
brain-umap@2
0.975
6SRR934921
brain-umap@2
0.974
7AA762299-102B-4E35-B4A5-A94A122EF9DB
brain-umap@2
0.974
8228C2042-804C-47FA-B565-1993E1015D40
brain-umap@2
0.974
930D8578D-0B48-4D03-9E39-6425494ECD5C
brain-umap@2
0.973
10A678E1E5-E02D-49A1-BB2B-C91A60E6382E
brain-umap@2
0.973

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 43 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.727Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.625Idelalisib— uncovered
MYC_TARGETS_V10.575Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.567Inavolisib— uncovered
MTORC1_SIGNALING0.565Inavolisib— uncovered
E2F_TARGETS0.564Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.532Idelalisib— uncovered
APOPTOSIS0.529Idelalisib— uncovered
G2M_CHECKPOINT0.509Inavolisib— uncovered
ANGIOGENESIS0.505Remibrutinib— uncovered
HYPOXIA0.502Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.493Inavolisib— uncovered
MYC_TARGETS_V20.488Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.479Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.474Inavolisib— uncovered
GLYCOLYSIS0.473Inavolisib— uncovered
DNA_REPAIR0.460Idelalisib— uncovered
ALLOGRAFT_REJECTION0.441Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.428Idelalisib— uncovered
COMPLEMENT0.419Inavolisib— uncovered