BS_273HKCT4
DNET
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- DNET
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- DNET
- age_years
- 6.868
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG491 | — | — | 0.901 |
| 2 | BS_264RCK7G | DNET | — | 0.894 |
| 3 | C3L-02958 | — | cohortA1 | 0.890 |
| 4 | BS_YNEQJ6AH | DNET | — | 0.881 |
| 5 | BS_0Y66ZBWE | low-grade glioma | — | 0.878 |
| 6 | BS_063ERW0R | pilocytic astrocytoma | — | 0.875 |
| 7 | BS_3P20Q2C3 | low-grade glioma | — | 0.871 |
| 8 | BS_9RT63JD9 | low-grade glioma | — | 0.870 |
| 9 | BSR_17_0022_E1_S60 | — | A | 0.868 |
| 10 | GSM6454733 | — | A | 0.864 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.263 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.250 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.238 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.201 | Cobimetinib | — uncovered |
| NOTCH_SIGNALING | 0.154 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.131 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.112 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.105 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.071 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.060 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.056 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.049 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.016 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.004 | Inavolisib | — uncovered |