SRR1318372
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.406
- MYOGENESIS+0.338
- KRAS_SIGNALING_DN+0.326
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.223
- SPERMATOGENESIS+0.208
- HEDGEHOG_SIGNALING+0.193
- FATTY_ACID_METABOLISM+0.170
- UV_RESPONSE_UP+0.089
- PEROXISOME+0.066
- XENOBIOTIC_METABOLISM+0.060
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.421
- G2M_CHECKPOINT-0.419
- PROTEIN_SECRETION-0.418
- ANDROGEN_RESPONSE-0.401
- IL6_JAK_STAT3_SIGNALING-0.393
- MITOTIC_SPINDLE-0.377
- E2F_TARGETS-0.353
- INTERFERON_GAMMA_RESPONSE-0.350
- INFLAMMATORY_RESPONSE-0.329
- TGF_BETA_SIGNALING-0.325
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1357434 | GTEX | — | 0.926 |
| 2 | SRR1468381 | GTEX | — | 0.907 |
| 3 | SRR1437538 | GTEX | — | 0.903 |
| 4 | SRR1459804 | GTEX | — | 0.898 |
| 5 | SRR1440308 | GTEX | — | 0.887 |
| 6 | SRR1468955 | GTEX | — | 0.884 |
| 7 | SRR1410264 | GTEX | — | 0.879 |
| 8 | SRR658247 | GTEX | — | 0.876 |
| 9 | SRR1440986 | GTEX | — | 0.874 |
| 10 | SRR1314767 | GTEX | — | 0.874 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.406 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.338 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.326 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.223 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.208 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.193 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.170 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.089 | Idelalisib | — uncovered |
| PEROXISOME | 0.066 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.060 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.053 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.034 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.033 | Temsirolimus | — uncovered |
| DNA_REPAIR | 0.028 | Idelalisib | — uncovered |