Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CN-6022-01A-21R-1686-07

7790fabd-98fa-5cbb-bf16-60fd5044a350

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.064155251
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYOGENESIS+0.520
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.480
  • ANGIOGENESIS+0.420
  • HEDGEHOG_SIGNALING+0.380
  • MITOTIC_SPINDLE+0.340
  • TGF_BETA_SIGNALING+0.340
  • WNT_BETA_CATENIN_SIGNALING+0.320
  • APICAL_JUNCTION+0.310
  • UV_RESPONSE_DN+0.270
  • INFLAMMATORY_RESPONSE+0.260

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.590
  • OXIDATIVE_PHOSPHORYLATION-0.460
  • INTERFERON_GAMMA_RESPONSE-0.410
  • FATTY_ACID_METABOLISM-0.320
  • CHOLESTEROL_HOMEOSTASIS-0.260
  • ESTROGEN_RESPONSE_LATE-0.210
  • HEME_METABOLISM-0.210
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.180
  • P53_PATHWAY-0.170
  • BILE_ACID_METABOLISM-0.160

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-CN-6989-01A-11R-1915-07
head-neck@1
0.856
2SRR25043621
head-neck@1
0.837
3TCGA-D8-A27H-01A-11R-A16F-07
breast-umap@18
E0.823
4SRR8943032
bladder-landscape@3
0.814
5SRR8613779
breast-umap@18
D0.799
6SRR5903555
lung-landscapes@6
cohortSQ10.798
7TCGA-A2-A4RX-01A-11R-A266-07
breast-umap@18
D0.794
8MBCProject_0217_T1_RNA
breast-umap@18
C0.792
9TCGA-55-A490-01A-11R-A466-07
lung-landscapes@6
cohortA10.791
10SRR27320698
colon-landscapes@1
0.790

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYOGENESIS0.520Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.480Inavolisib— uncovered
ANGIOGENESIS0.420Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.380Inavolisib— uncovered
MITOTIC_SPINDLE0.340Inavolisib— uncovered
TGF_BETA_SIGNALING0.340Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.320Inavolisib— uncovered
APICAL_JUNCTION0.310Inavolisib— uncovered
UV_RESPONSE_DN0.270Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.260Idelalisib— uncovered
HYPOXIA0.250Idelalisib— uncovered
KRAS_SIGNALING_UP0.250Inavolisib— uncovered
NOTCH_SIGNALING0.220Inavolisib— uncovered
COAGULATION0.210Binimetinib— uncovered
G2M_CHECKPOINT0.190Inavolisib— uncovered
PANCREAS_BETA_CELLS0.180Cobimetinib— uncovered
COMPLEMENT0.150Inavolisib— uncovered
GLYCOLYSIS0.140Inavolisib— uncovered
IL2_STAT5_SIGNALING0.090Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.090Inavolisib— uncovered