9176b038-65e3-469d-a867-d99bc732e45d
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 80
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.310
- HEDGEHOG_SIGNALING+0.220
- NOTCH_SIGNALING+0.220
- P53_PATHWAY+0.190
- IL6_JAK_STAT3_SIGNALING+0.180
- ESTROGEN_RESPONSE_EARLY+0.160
- MYOGENESIS+0.160
- COAGULATION+0.150
- KRAS_SIGNALING_DN+0.150
- XENOBIOTIC_METABOLISM+0.080
Top 10 suppressed
- E2F_TARGETS-0.500
- G2M_CHECKPOINT-0.500
- MYC_TARGETS_V1-0.500
- MTORC1_SIGNALING-0.470
- ANDROGEN_RESPONSE-0.410
- PROTEIN_SECRETION-0.400
- OXIDATIVE_PHOSPHORYLATION-0.380
- CHOLESTEROL_HOMEOSTASIS-0.340
- INTERFERON_ALPHA_RESPONSE-0.320
- MYC_TARGETS_V2-0.290
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-1121 | Med | Medulloblastoma | 0.908 |
| 2 | TCGA-A7-A426-01A-22R-A24H-07 | — | A | 0.890 |
| 3 | TCGA-D8-A3Z5-01A-41R-A24H-07 | — | A | 0.883 |
| 4 | MDT-AP-1356 | Med | Medulloblastoma | 0.875 |
| 5 | MNG1258 | — | — | 0.866 |
| 6 | d406bb03-1a9a-4aa3-a1a8-4de5478b4701 | — | — | 0.865 |
| 7 | MBCProject_0003_T2_RNA | — | A | 0.863 |
| 8 | MDT-AP-1132 | Med | Medulloblastoma | 0.860 |
| 9 | TCGA-A2-A0CK-01A-11R-A22K-07 | — | A | 0.852 |
| 10 | TCGA-AC-A3W7-01A-11R-A22K-07 | — | A | 0.850 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.310 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.220 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.220 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.190 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.180 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.160 | Inavolisib | — uncovered |
| MYOGENESIS | 0.160 | Inavolisib | — uncovered |
| COAGULATION | 0.150 | Binimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.150 | Remibrutinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.080 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.050 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.030 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_UP | 0.020 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.010 | Cobimetinib | — uncovered |