TCGA-WA-A7H4-01A-21R-A34R-07
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.440
- ANGIOGENESIS+0.270
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.270
- HEDGEHOG_SIGNALING+0.160
- COAGULATION+0.120
- PANCREAS_BETA_CELLS+0.090
- KRAS_SIGNALING_DN+0.060
- KRAS_SIGNALING_UP+0.030
- PROTEIN_SECRETION+0.030
- UV_RESPONSE_DN+0.010
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.640
- CHOLESTEROL_HOMEOSTASIS-0.570
- INTERFERON_GAMMA_RESPONSE-0.560
- MTORC1_SIGNALING-0.550
- TNFA_SIGNALING_VIA_NFKB-0.540
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.530
- MYC_TARGETS_V2-0.510
- MYC_TARGETS_V1-0.470
- E2F_TARGETS-0.440
- HYPOXIA-0.440
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-CN-4737-01A-01R-1436-07 | — | — | 0.915 |
| 2 | e3d71c3f-4e56-45fa-be88-2cf444b70a5c | — | — | 0.901 |
| 3 | SRR33346962 | — | — | 0.897 |
| 4 | SRR12202443 | — | — | 0.891 |
| 5 | MBCProject_0589_T1_RNA | — | A | 0.891 |
| 6 | SRR23303745 | — | — | 0.883 |
| 7 | SRR1516070 | — | — | 0.879 |
| 8 | TCGA-CQ-7072-01A-21R-A30B-07 | — | — | 0.878 |
| 9 | SRR12696774 | — | — | 0.878 |
| 10 | SRR1335254 | GTEX | — | 0.874 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.440 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.270 | Remibrutinib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.270 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.160 | Inavolisib | — uncovered |
| COAGULATION | 0.120 | Binimetinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.090 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.060 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_UP | 0.030 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.030 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.010 | Inavolisib | — uncovered |