Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-A7-A0DB-01A-11R-A277-07

· D

7ab5fdfb-b2ed-5fc0-8efa-f9a5de20f611

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
34
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • UV_RESPONSE_DN+0.370
  • PROTEIN_SECRETION+0.300
  • ANDROGEN_RESPONSE+0.200
  • KRAS_SIGNALING_UP+0.180
  • BILE_ACID_METABOLISM+0.170
  • MITOTIC_SPINDLE+0.170
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.090
  • SPERMATOGENESIS+0.080
  • FATTY_ACID_METABOLISM+0.070
  • TGF_BETA_SIGNALING+0.070

Top 10 suppressed

  • MYC_TARGETS_V2-0.580
  • DNA_REPAIR-0.430
  • INTERFERON_ALPHA_RESPONSE-0.410
  • MYC_TARGETS_V1-0.400
  • UV_RESPONSE_UP-0.370
  • E2F_TARGETS-0.360
  • TNFA_SIGNALING_VIA_NFKB-0.360
  • INTERFERON_GAMMA_RESPONSE-0.300
  • OXIDATIVE_PHOSPHORYLATION-0.300
  • PANCREAS_BETA_CELLS-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SJEPD030399_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.885
2TCGA-A7-A13G-01A-11R-A13Q-07
breast-umap@18
D0.854
3TCGA-A7-A26E-01A-11R-A169-07
breast-umap@18
B0.841
4TCGA-A7-A0DB-01C-02R-A277-07
breast-umap@18
D0.840
5TCGA-BL-A0C8-01B-04R-A277-07
bladder-landscape@3
0.821
6SRR655555
brain-umap@2
GTEX0.820
7TCGA-A7-A26E-01A-11R-A277-07
breast-umap@18
D0.809
8ERR2598056
medullo-epn-umap@date-based
fetalfetal0.806
9MDT-AP-3025
medullo-epn-umap@date-based
MedMedulloblastoma0.803
10TCGA-44-6147-01A-11R-A278-07
lung-landscapes@6
cohortMD20.803

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 12 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.370Inavolisib— uncovered
PROTEIN_SECRETION0.300Remibrutinib— uncovered
ANDROGEN_RESPONSE0.200Inavolisib— uncovered
KRAS_SIGNALING_UP0.180Inavolisib— uncovered
BILE_ACID_METABOLISM0.170Inavolisib— uncovered
MITOTIC_SPINDLE0.170Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.090Inavolisib— uncovered
SPERMATOGENESIS0.080Inavolisib— uncovered
FATTY_ACID_METABOLISM0.070Inavolisib— uncovered
TGF_BETA_SIGNALING0.070Inavolisib— uncovered
HEME_METABOLISM0.050Temsirolimus— uncovered
ANGIOGENESIS0.030Remibrutinib— uncovered